Statin discontinued due to neuropathy. What are some alternatives?

Posted by Nazir Khan @nukhan, Jan 19, 2020

I have been using Lipitor since 2007 for lowering my cholesterol which is on the list of those medicines that are suspected to cause neuropathy. I am thinking of discontinuing this menace but before doing so want to check with those members who have discontinued using statin and what is their experience. What alternative methods have they since adopted for lowering their cholesterol .. diet, alternative medication, exercise or anything else ?

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@dutchman09

Has anyone here been diagnosed with Peripheral Neuropathy caused exclusively from orally ingesting a statin medication for 8 years? I have never had diabetes or high Cholesterol.

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I don't think most doctors know that statins can cause neuropathy! A study I read said long -term use was greater than 1 year. Most of us get put on them for years and years. I stopped mine. My diet is excellent, but my LDL is high no matter. I am trying Zetia after going off rosuvastatin about 8 months ago. Hopefully, it's working well enough. I test again in the fall.

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There is an injectable now your doctor can prescribe.

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@vogie

I am a 69 year old female who has always had a normal BMI and a good fitness level. My labs have always been completely normal except for the lipids. I am on the athletic side. I am a life long exerciser. The only prescriptions I have ever taken on a regular basis are for HRT, which I started in my early fifties and continue to take.

I have resisted my doctor's urging me to take statins for years, as I have very high cholesterol. Male family members have taken statins and continue to take them while enduring long term muscle pain and muscle wasting. My father died at 53 from a heart attack, and his father at 60-so I can understand their risk/benefit analysis.

I was finally bullied into starting statins by my husband and several doctors last year. I started Rosuvastatin in March 2024 and experienced crippling muscle pain in my legs the following summer. I was eventually switched to Atorvastatin . Within 2 weeks of starting this statin I developed neuropathy in my hands and feet which greatly interfered with my sleep. On one day only, I experienced the tingling all up and down both arms and legs as well. This was a ghastly and very frightening experience. The neuropathy has been intermittent since, and limited to my hands and feet with an odd shooting tingly in other random spots, very occasionally.

Doctors dismissed the muscle pain and the neuropathy as extremely likely to be unrelated to the two statins. One said that there is absolutely no evidence that either statin causes these conditions. I feel like I am being gaslighted.

I discontinued the second statin. I was also starting to see my glucose numbers rise, but they were still in range

Now I am taking Repatha for cholesterol and gabapentin for the nerve pain. I see a neurologist for the nerve pain and will be undergoing further testing. She prescribed the gabapentin. I am taking 300 mg at bedtime. The worst side effects from these are fatigue, though I do get tremendously good sleep since starting the gabapentin-which is why she prescribed it. The gabapentin makes me very relaxed and limits my interest in exercising, although I am much calmer and less type A than I was prior.

My glucose A!c hit 6 on my blood work last week. I was consistently in the mid 5s for many many, years prior to starting stains and Repatha. I have read that medication induced diabetes may be irreversible, and I find that very scary. My energy levels are quite low and my weight has been rising rapidly. I am up from 135 to 153 since March 24. I am 5'2. None of my clothes fit and my lifelong motivation to exercise has waned.

Now the doctor in cahoots with my husband are recommending Zepbound for weight loss and blood sugar control.

I am thinking I would rather stop all these medications and just live with high cholesterol.

Anyone with similar experience?

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Hello @vogie,

I see this is your first post on Connect, welcome! I have taken statins for at least 20 years now and put if off for several years before then. My lipid numbers were generally well controlled. However, two years ago, my triglycerides jumped up over 300, and my doctor and I were surprised. Like you, I have a BMI of 23, and there had been no change in my lifestyle (eating, exercise) as well as no change in stress levels (stress can play havoc with all of our bodily systems).

So we tried adding a new drug, which resulted in too many side effects. The cardiologist then prescribed a prescription-strength Omega-3 drug called Lovaza. My prescription plan did not cover it; however, I found it on GoodRX for $40 a month. After one month of use, my doctor ordered lab work. My triglycerides, which had been over 300, were now in the range of 100's. My cholesterol had also dropped about 100 points.

While we all react to medications and supplements differently, you might request a prescription for Lovaza to see if it would help you. I'd love to hear from you again. Will you post updates as it is convenient?

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Leqvio is not a statin. I use it. Take one shot, three months later another shot and then every six months. It has brought mine down.

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I was able to switch to a non-statin (I refuse to take statins) called Zetia. It’s been very effective.

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Many years ago, when i was first told i had high cholesterol, all i did was watch what i bought. Canned soup, looked for cholesterol amounts, etc. And I ate oatmeal every morning, as i heard it helps . I watched what i ate in regards to cholesterol, plus the oatmeal, and after 2 or 3 months, my cholesterol went down. But, then over the years, i sort of went back to eating every thing. the last few years, I decided to take a couple of supplements, One is Cholest MD, i get from amazon. It has Citrus Bergamot, plus i take additional citrus bergamot from HP Life Science., and also Berberine. Garlic really does not help., but, it still is good for the heart. when i take these every day, then my cholesterol levels drop, even when i eat limited amounts of ice cream. Also as we age, my primary care dr, along with many info on websites, state, that when you get older, i would ....assume.....over 60, not sure what age, you need a little more cholesterol. I will not let mine go below 200 total. And by taking high doses of vitamin C daily, my arteries are clear. Over 25 years, i have checked, with ultrasounds, how my arteries are. when i back off the vitamin C.........they get a mild build up. then i go back on aprx 4,000 mg a day, when i do another ultrasound, they are clear again. I used to think it was coincidence. but, i've had so many ultrasounds, when i reduced the C, then after increasing it for a few months, it is then always clear., so for me, that works. I'm not sure, but i think i read many years ago, that if you have kidney problems, not to take high doses of C. well, i have stage 3 kidney failure, which cold be from several uti's, and all the anitbiotics, But.....I still do C..because i wan to keep my arteries clear. I don't know of anyone else who does this, but, after many many ultrasounds, no one will be able to convince me, that it is just a fluke. and it is Not diet. I still eat junk food, tho i try not to go overboard. I am not suggesting anyone do what I do.......this is just an avenue to check out. A Naturopath Dr., would have better info on alternative treatments, then an MD. They study alternative solutions, MD., study drugs. Which we do need............but.........when one fails, you might want to seek out different solutions. PS, none of my dr.s even alternative, told me about the High C........i found it out from a magazine, from an alternative dr, who uses it in her clinic. I decided to try it, and am quite happy with the clear arteries. Even with cholesterol of 280, they are still clear. Never rush out to buy anything that works for one person. Someone could have other health problems where an herb or supplement could do harm, instead of help.

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@storoe

Hello, can you give more information on the sources for the screen shot you posted?

thank you, roger

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Hello,
Just letting you know my primary care physician had me stop the statin cholesterol medication February of this year. My LDL went up quite a bit. I saw my PCP again today and she prescribed a non statin medication which I picked up and will start it tomorrow. I see the doctor again in 3 months to check if the new medication is working.
Therefore, there are other non statin options available but you really should check with your doctor.
I wish you the best.
Take care and have a serene weekend ahead.
gus

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@storoe

Hello, can you give more information on the sources for the screen shot you posted?

thank you, roger

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Can't really help you there. I have saved information as I found it over the years. This was one bit of info that helped me make a decision. I can only suggest you try looking into the topic as well. I do tend to used Scholar Google, PubMed, National Institutes of Health and Mayo Clinic most often.

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@mamamarch

I've attach a screen shot from some of my previous "research" that may help. There are some statins that are less likely to exacerbate the neuropathy. The best is expensive, so I choose rosuvastatin.
Your doctor will possibly resist because he or she doesn't believe the relationship between statins and neuropathy. Or may just feel that it's a choice between two issues and one is more deadly than the other. I was able to convince mine and she was very "cooperative" with my efforts. I read that very low doses of a statin are as effective if not more so than the normally prescribed dose. I reduced my dosage from 20mg to 10, then 5 and eventually down to 5mg every other day. This low dosage was able to keep my total cholesterol level right at 200, which was fine by me and acceptable to my doctor.
Another thing to seriously consider is supplementing with CoQ10 (or it's better form, Ubiquinol.) The should help to protect the nerves as well.
Just my thoughts, but seems to work well for me.

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Hello, can you give more information on the sources for the screen shot you posted?

thank you, roger

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@mamamarch

I've attach a screen shot from some of my previous "research" that may help. There are some statins that are less likely to exacerbate the neuropathy. The best is expensive, so I choose rosuvastatin.
Your doctor will possibly resist because he or she doesn't believe the relationship between statins and neuropathy. Or may just feel that it's a choice between two issues and one is more deadly than the other. I was able to convince mine and she was very "cooperative" with my efforts. I read that very low doses of a statin are as effective if not more so than the normally prescribed dose. I reduced my dosage from 20mg to 10, then 5 and eventually down to 5mg every other day. This low dosage was able to keep my total cholesterol level right at 200, which was fine by me and acceptable to my doctor.
Another thing to seriously consider is supplementing with CoQ10 (or it's better form, Ubiquinol.) The should help to protect the nerves as well.
Just my thoughts, but seems to work well for me.

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Thank you 🙏helpfull info.

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