Degarelix vs Relugolix?

Orgovyx is a big improvement over monthly Degarelix injections. Side effects are quite similar. Some people have fewer side effects them with other ADT drugs. No matter what is an improvement and you should go for it.

You take it once every day if you don’t like it, you can always switch

2½ years on Degarelix, then one year on Relugolix (so far).

No comparison: my quality of life is massively improved without the monthly injections, swelling, rashes, and 2–3 days of flu-like symptoms. My other side effects, like hot flushes and fatigue, also seem diminished, but that might just be my body building up a tolerance after several years on ADT.

Note that I'm also taking Apalutamide (Erleada), since my cancer is metastatic.

Thanks, North My PCa is metastatic as well and I forgot to mention that I'm also taking Abiraterone (Zytiga) along with 5mg prednisone. I was taking 1.0 gram daily but my Onc dropped it to just 250 mg daily taken with a lo-fat breakfast citing a new study that suggests the lower dose regime works just as well. Lo-fat anything has never really been part of my diet plan but I'm adapting. 🙂

I responded very badly to Prednisone when I was getting it to try to reduce the swelling in my spine post-surgery and relieve the pressure on the spinal cord -- I ended up with steroid-induced diabetes, and the hospital nurses had to give me regular insulin injections (the diabetes cleared up almost immediately after I stopped).

Most people here seem to tolerate steroids fine — I guess I'm an exception — but I still suggest that you talk to your medical team about the Prednisone as well as the ADT as a possible source of any side-effects you're experiencing. I don't know if that's why my oncologists recommended Apalutamide instead of Zytiga for me in 2021 (the -lutamides doen't require a steroid); the TITAN study was also just out, showing a huge improvement in delaying progression and overall survival in patients with mCSPC taking ADT+Apalutamide.

I know a few people that are doing this and it works just great. Many doctors aren’t offering this option, usually, the people I know I’ve had to ask for it. Sounds like you have an enlightened doctor.

Interesting to hear your problem with prednisone, it never bothered me. I tried to switch to dexamethasone because I read studies that showed that it worked better than prednisone with Zytiga, and would allow you to stay on Zytiga longer. Only Need to take .5mg compared to 5mg with Prednisone.

Turns out dexamethasone causes my heart to start putting out extra beats after taking it for a couple of days. Do enough of those and one can end up in afib. Kaiser put dexamethasone on the list of drugs. I am allergic to.

Strange drug interactions for both of us.