Cymbalta stopped working. What now?

Posted by lantana @lantana, Oct 1, 2025

I was on prozac for many years and finally decided it wasn't working. The psychiatrist then prescribed Cymbalta. I did improve, or at least thought I did, but now I know it isn't working. Firstly, I'm now 83 and hate being old. I've had major back surgery and have periodic times during the day when I need to rest. I no longer look like myself and find that depressing. I'm tired, have no interest in anything, my husband is boring and I don't confide in him because he comes up with platatudes. I have friends, all widows, but I never look forward to anything. I just pretend.

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I am 65 and after hormone blocker treatment for breast cancer ( let alone the effects of getting old ) I dont look like me anymore I look like a skeleton in the face all the other health issues, lost weight now Im gaining again.. hair loss now as well. I was on cymbalta then got off it, tried another it has stopped working some are lucky when it comes to medications some are not. Doc wants me on another med,.

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I’m sorry to hear that your medication has stopped working, this is a serious concern and it seems to be affecting many people who are on different medications. Ever since I can remember I was always weary of medications, I saw how much the doctor kept giving to my mom, in fact she gathered up meds with every doctor she went to…I knew that she had mental health problems with depression and anxiety but sometimes her meds affected her too much and I would take her to the hospital, one doctor said she was on too many drugs and it was causing strong symptoms. It is well known that doctors over medicate seniors and if you complain about it they give you something else to take. I realize that some medications are necessary for survival but we need to use our own judgment about how to handle this issue, I think that we are relying too hard on a medication that will help us to survive but sadly, they come with their own problems and it just builds up in our bodies, I wonder sometimes how well we can do without accepting more medication.

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There are reports of meds not working once switched to generic. Cymbalta is now off the market and only the generic is available. Perhaps something to discuss with doc

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Profile picture for laura1970 @laura1970

There are reports of meds not working once switched to generic. Cymbalta is now off the market and only the generic is available. Perhaps something to discuss with doc

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@laura1970 Thanks. I will definitely talk to my doctor.

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