Anyone in Clinical trial for MEK Inhibitor IMM-1-104. NCT05585320?

I see in this article that the FDA has given fast track designation to IMM-1-104 for use as a therapeutic option in patients with pancreatic ductal adenocarcinoma (PDAC) who have progressed on 1 line of treatment.

- FDA Grants Fast Track Status to IMM-1-104 for Pancreatic Cancer https://www.onclive.com/view/fda-grants-fast-track-status-to-imm-1-104-for-pancreatic-cancer

Here is a link to the clinical trial itself
- A Phase 1/2a Study of IMM-1-104 in Participants With Advanced or Metastatic Solid Tumors http://cancer.gov/research/participate/clinical-trials-search/v?id=NCI-2023-00995

@sandyk62, are you eligible for the study? Have you enrolled?

I will be at Mayo Rochester next week for all my pre-screening appts. Mayo had recommended this trial, it will be a 1st line treatment since I now have a few liver lesions since my whipple last September. So if all goes well next week I will start this clinical trial in a couple of weeks at Mayo.
Thank you for the follow up informational links.

My husband is enrolled with NextOncology, we are new to this, same drugs so assume same trial? Just started last week, side effects minimal so far, which is great.

I’m heading to SCRI in Nashville, TN for all the pre-testing for the IMM-1-104 tomorrow and Tuesday. I will sign my consent form tomorrow. I had all this testing done once with Mayo, but after the testing was completed Mayo didn’t have a slot available for me. So now I’m going to Nashville, TN for the trial. Nashville has confirmed that they do have a spot for me. Yay!!!
Where is your husband doing his clinical trial at? Has he had any side effects?
I pray you and your husband have a positive outcome with this trial. I know it is hard but try to keep a positive attitude and try to keep doing activities that bring you joy. I find that it has really helped me and my family.

Looking forward to your updates. Hopefully this is the one that works for.all. Who did u.contact to enroll? Do you have to go there for the.trial?

Do you have to go to Nashville for every trial session? How often?

Yes, you will have your treatment in Nashville.
1st step - contact SCRI and tell them your interested in the IMM-1-104 clinical trial (Nashville refers to the study as RM 1070)
2nd step - they will get you an appt with the oncologist that is the leaders of the study, we met with Meredith Pelstar.
3rd step - do your pre-testing procedures, if you want to be in the study. Nothing too crazy, labs, heart ultrasound, CT of abdomen/chest/pelvic, and eye exam

Frequency of visits after you start the trial -
Month 1. Day 1, 2, 8, 15
Month 2+. Day 1 and 15

Good luck
Sandy

Sorry, I misspelled the doctor name.
Meredith Pelster, MD

Sending healing thoughts and prayers your way. We were fortunate to find this trial near our home in Virginia, we are working with Virginia Cancer Specialists and Next Oncology for the trial. He has so far had 2 chemo infusions and has been taking the IMM drug orally since 6/4. Thankfully, side effects have been minimal. He does think he is starting to lose his hair, but has not thrown up and has dealt with just some minimal nausea, which was controlled pretty well with medications. He's very tired, eating continues to be interesting, but overall we are thrilled. We are still looking into alternative and integrative solutions and treatments as well.

My husband began this trial on 6/4. He's about to have his 3rd chemo infusion, the IMM drug is taken orally each day. So far, so good...no terrible side effects and he's feeling OK. His tumor is not operable, so we are still investigating everything else we can find, including a trial in Spain for something called histotripsy. He has to have at least 8 chemo treatments before applying for that one. His tumor is inoperable due to impingement of major vessels so we are hoping this might be a means to get it out.