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Cialis / Tadalifil muscle ache - any advice?

Posted by fritzo @fritzo, 1 day ago

Hi everyone,
Ahead of surgery in three weeks, I started a low dose regimen of daily 5mg of Tadalifil . I've started getting one of the known side effects where I suffer muscle pain (mainly my thighs/quad muscles in the legs and my shoulder muscles). I would describe it as a deep muscle ache. It's annoying enough that I haven't gotten great sleep the past couple of nights. I did wake up last night and took some Tylenol and that helped.

Question: Any strategies for dealing with tadalis induced muscle ache? Does it go away? Should I switch from taking it at night to the morning?

Thanks for any advice!

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jheadding | @jheadding | 16 hours ago

Same here, I started on 5 mg daily for about six months (post SBRT) and noticed the exact same side effects as you including Some low back pain as well. When I did a trial of discontinuing the drug, the side effects disappeared. I have gone to 5 mg every other day and found that this helped reduce the side effects.(I am 73 years old so expect that my tadaladil half life might be a bit longer due to age.) If the side effects continue, you might consider switching to Viagra or sildenafil 25mg daily. Tadalafil’s PDE 11 effect is the cause of these specific side effects. Sildenafil lacks PDE 11 inhibition. Good luck!

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fritzo | @fritzo | 12 hours ago
In reply to @jheadding "Same here, I started on 5 mg daily for about six months (post SBRT) and noticed..." + (show)
Profile picture for jheadding @jheadding

Same here, I started on 5 mg daily for about six months (post SBRT) and noticed the exact same side effects as you including Some low back pain as well. When I did a trial of discontinuing the drug, the side effects disappeared. I have gone to 5 mg every other day and found that this helped reduce the side effects.(I am 73 years old so expect that my tadaladil half life might be a bit longer due to age.) If the side effects continue, you might consider switching to Viagra or sildenafil 25mg daily. Tadalafil’s PDE 11 effect is the cause of these specific side effects. Sildenafil lacks PDE 11 inhibition. Good luck!

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@jheadding Thanks so much! Glad to know I'm not the only one out there. It appears to be one of the rarer side effects. Not much out there on the web about it, but it is known.

I'm starting by switching to taking it in the morning. Apparently, the muscle ache is described in the literature as being typically worse when lying down, so going to see if taking it in the morning vs. night might help.

From there, I'll probably end up talking with my doc whether to switch to other PDE5 med or just alternate dosing. One person tole me that they switched to taking a 10mg Tadalafil every other day and that helped them.

It did really have me confused at first because I've been do vigorous walking on the treadmill with a weight vest to get in better shape pre-surgery....so I was wondering if that was why my thighs/shoulders were hurting so much. So, good news, no, not the treadmill. Bad news-it's the new drug.

We'll get there. Thanks for your help!

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