Castration resistance

Posted by johndavis60 @johndavis60, 2 hours ago

What are the modern strategies to delay castration resistance? In my case, I will be on Firmigon (or Orgovyx) for 36 months and Xytiga, for 24 months. At least that’s the plan. I was told that adding xytiga now will help the radiation and keep any residual cancer at bay for longer as well as delaying castration resistance. What happens to the ADT strategy when those 1st drugs become non-effective? Do people try different drugs? My oncologist isn’t real excited about the efficacy of pluvicto in general, plus it wouldn’t work for me anyway. In my case would I move to Ellegard and/or Nubeqa? Thanks 🙂

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jeff Marchi | @jeffmarc | 10 minutes ago

I became castrate resistant 2 1/2 years after starting ADT. My oncologist actually put me on Biclutamide for a year and then Zytiga for 2.5 years. I started having some real heart issues with Zytiga So I switched over to Darolutamide and I have been undetectable for 20 months. It has been six years since I became castrate resistant. These newer drugs really help.

The one metastasis I had was on my spine on L4. Had it zapped a couple years ago with SBRT.

Now the bad news

While the median overall survival (OS) for mCRPC patients is often cited as around two years, it's crucial to understand that this is a median, meaning that half of patients live longer than this, and half live for a shorter duration.

Survival times vary greatly among mCRPC patients, influenced by factors like the extent of the disease (where it has spread, whether it is high volume or low volume disease, etc.), overall health, and response to treatment.