Can anyone share their experience with Pluvicto?

Could have. All things are possible, but not probable.

Promise/Color, oh, you're good, not hereditary, don't have to inform kids.

1.5-2 years later,things don't seem to be following "the plan", onc sent sample off to a lab in Chicago.
Just so you might clearly understand, this was not a NEW biopsy sample, this was a bit of the ORIGINAL biopsy sample.
I suppose sitting in a refrigerated space all that time, the DNA in the sample could have transcended earthly bounds and become something else for the next test.

Nah.

Ooooops. New lab says it IS hereditary, and oh, by the way, it's ATM variant.....and then the onc changed "the plan" because those meds were not best for ATM.

Doesn't matter.
I don't trust medical professionals any more.

You could have had two different somatic tests, Or you had a hereditary test and a somatic test. The cancer can cause the somatic DNA test to change, So you can have a different result after a test run some time after the previous test.

Yeah, we'd researched that 1/3-1/3-1/3 bit. I am ATM.
Anymore, don't trust the science. Just go with the flow and see what happens.
Had two of those genetic tests. Two different results.

I had to go back and review my nuclear protocols. Just to make sure. All those years on Nuke subs, at least we joked when we said "when they turn off the lights, I glow in the dark!"
Did you know with Pluvicto some folks promote Geiger counters and pocket dosimeters? A tad overkill with a short half-life.
Some folks say 30-day half-life, looking up Lutetium 177, half life is 6.65 days. Fits into 2-3 feet from children for 6-7 days.
Right now, with the majority of Docetaxel out of my system, been doing yard work. Been a long time.

My husband had six Pluvicto infusions over most of 2024 and had none of the severe side effects that some people experience. He had some fatigue, a dry mouth from his saliva glands being affected by the treatment, and his appetite for food decreased in that most things just didn't appeal to him. His last Pluvicto infusion was in August 2024, and the only side effect remaining is dry mouth. Please don't worry about the radioactivity warnings; your doctor or treatment staff should tell you what is necessary, and it is much less than the overkill that some men do. No need to buy a Geiger counter or totally isolate yourself for days! Congratulations on starting Pluvicto, and good luck to you.

I’ve never had it. I’ve been to quite a few online conferences where they spend an hour on it. A few people over at Ancan.org Weekly advanced prostate cancer meetings, have had it and discuss side effects.

What was your experience with Pluvicto?

Be aware that Pluvicto works really well for 33% of people OK for 33% of people and not at all for 33% of people.
If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a hereditary and somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer.

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant. I don’t know if these are the only genetic changes that cause Pluvicto to work much better or more poorly.

3+ years of fighting, failed chemos, sometimes horrible side effects, but tomorrow (Tuesday 24JUN25) I start Pluvicto.
Good to read some of this. The on-line side effects are....scary. The MD's keep adding to the list the closer we get to radioactivity.

Hello. I’m the widow of a Pluvicto treated Awesome Godly Man! He was advised to have the chemo before the Pluvicto. Don’t tell my husband Not to do something. He was Always “game on,” when it came to his cancer treatment. Granted he was a 20+ year survivor of Melanoma-from 2002-do I need to tell you BRCA2. Anyway, he passed away 9/11/2024; yet retired from full time work 9/1/2024, although bedridden Hospice at that point. Driving and working until 8/9/2024. He completed his last Pluvicto #6 on 5/14/2024. He had absolutely no side effects from Pluvicto, especially when we realized Zofran caused constipation and told his team he wasn’t taking the Zofran. The “chemo wrecked me.”
There’s So much more to his story, but fight fight fight is what my husband chose to do and we supported him all the way. He was 68 years old. I was an Emergency nurse for 30+ years and a Hospice nurse 41 years ago. Every single human is different. Godspeed and blessings to all of you.