Can anyone share their experience with Pluvicto?

I am 81 years old, coming to the end of the proverbial five year life cycle of stage IV prostate cancer which has metastasized throughout my bones and lymph nodes. I have had every treatment protocol available except chemotherapy which was my choice to not have.

I took the full Pluvicto course of six infusions, six weeks apart. I have to say I am the poster boy for Pluvicto. I tolerated it quite well. That is not to say that your results would be the same.

Every treatment has its better days and worse days. For me, the Pluvicto course was filled with way more better days than worse.

Yes, I had PET CTs prior to (2021), mid way through and after (6-22) my Pluvicto treatments. The treatments resulted in a remarkable reduction of lesions/tumors. Two years afterwards (6-24), things turned down, again and I am repeating the full 6 treatments under a very special arrangement. After the 3rd, treatment, 9 overall to-date, I had another PET CT to confirm the treatments are working, again. They are, and I will continue to receive the last 3 within the next 18 weeks.

Thanks for sharing your Pluvicto infusion story... I just finished my six infusions. I had a PSMA scan after the first four infusions, and it showed that the infusions had been beneficial in regards to my bone metastises... Question for you--- Did you have any bone scan (not bone density) after your fourth infusion?? If so, did you then have another scan after your sixth infusion to see what benefit there was (or not)??

Thanks again for your time/information... Mark

I am a 72 yr old dealing with the same thing all of you are, stage IV Prostrate cancer. Diagnosed about 10 years ago. Redroadrunner could have written my story, with the exception of I did go through chemo to arrive at Pluvicto.
Interesting how many of you bought Geiger Counters, I thought I was the only one, or at least in the minority.
I just received # 3 infusion about a week ago and the side effects, although not terrible, are worse.
Strangely I seem to have developed the symptoms best described as gout.
Pain in the joint of my big toe. This is what brought me to this website/thread.
I’m not sure it is a side effect of the Pluvicto, but I’ve never had gout before and I there is nothing in my diet that would cause it.
I didn’t “flush” (drink water) as much as I should have yesterday and the pain, that was subsiding, is worst today.
I am only halfway through but so far the side effects are fairly mild. Chemo was much worse.
I’ve always taken the approach that doing nothing was not an option. So I will take advantage of whatever treatments are available.
My quality of life is still very good and as long as that is the case I will continue.
Thank you all for your posts, I enjoyed reading them very much. We’re not alone.

Thank you for sharing! Mine is similar, and yet I am still fighting as you are! Stay strong!

A prostate-specific antigen (PSA) flare occurs in about 15% of metastatic castration-resistant prostate cancer (mCRPC) patients receiving docetaxel. This flare has no standard definition. Its impact on treatment efficacy is unclear. We sought to evaluate the incidence and characteristics of PSA flare on cabazitaxel, and its impact on survival.
https://www.sciencedirect.com/science/article/abs/pii/S0959804914002706#:~:text=A%20prostate%2Dspecific%20antigen%20(PSA,on%20treatment%20efficacy%20is%20unclear.
BTW my PSA flared from 41 to 159.3 Oncologists said must do 12 weeks then see just did second chemo I am 80 and feel great Mets in T5 and L4 and hip Pain first 4 days but on pain killer's Tylenol and some more powerful Options arc 177 or clinical trial OS maybe 13 to 25 months

WHAT about chemo with Cob?> Or this What is the most powerful chemo drug?
Red Devil Chemo: What to Know About Doxorubicin
Doxorubicin is one of the most powerful chemotherapy options for a wide range of cancers. Because of the way it works, doxorubicin can kill cancer cells at any point in their life cycle.Sep 28, 2023

Study PSA flare with both Chemo and 177

COPY Overall, 125 patients were included. Median PFS and OS were 6.5 and 13.3 months, respectively. Depending upon the definition used, flare incidence ranged from 8.3% to 30.6%. The flare lasted < 2.6 months. A PSA flare followed by a ⩾50% decrease was associated with a median PFS and OS of 11.2 and 25.2 months, respectively. Median PFS and OS for a ⩾30% rather than ⩾50% decrease were 10.4 and 16.5 months. These outcomes were not significantly different from those in patients with immediate PSA decreases of ⩾50% or ⩾30% from baseline, but were significantly better than in patients experiencing no PSA decrease (p = 0.006 and 0.015, respectively, for OS).
Conclusion
The PSA response to cabazitaxel, with or without initial flare, was associated with a strong survival benefit. The taxane-induced flare during the first 12 weeks of therapy can be ignored when evaluating PSA response.

Pluvicto was started as my PSA abruptly increased from a low of 8 after doxetaxel treatment to 17 a few months later. By the time Pluvicto was started the PSA was 198.
After the first infusion, the PSA dropped to 100. After the second infusion, up again to 120. After the third infusion, the PSA was 364 - obviously a treatment failure. Options now are essentially nonexistent. I am unwilling to accept the debilitating side effects of a repeat doxetaxel ( or other chemo agent) for minimal short term benefit.

Did it work What is PSA What is status of PC metaseries Bone?

Thank you for this information. My husband is on Medicare and 6 treatments are what they have approved. I have not heard of any private insurance companies that would cover more treatments.