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Can anyone share their experience with Pluvicto?
My 85 year old dad has prostate cancer that has metastasized to his bones. Zytiga is no longer effective. He is considering Pluvicto. I would appreciate input from those who have used Pluvicto.
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It took a day before I felt any change and then rebounded back to normal in 3 or so days after each treatment. I could tell I was a little more fatigued after treatments 5 and 6, but it didn't interfere with my daily routine. I made sure to eat well, get a night's sleep and sometimes took a short nap during the day. Overall, for me, it wasn't a big deal. I hope you do well, too.
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1 ReactionThank you for sharing. Husband started first Pluvicto treatment and is only suffering from fatigue. From your comments it sounds that as the treatments continue, the side effects get worse. Is that true?
In response to jay0013:
I was a Pluvicto clinical trial patient 2021-22 and responded remarkably well. It was a full 22 months after the final treatment before my PSA began to rise again and tumor growth was detected. The only side effects (other than being radioactive) were a day or two of feeling a little funky from the Lu-177 and some, but minor fatigue toward the end of the 6th treatment.
I am now repeating the 6 treatments (completed #4 of 6) via a special arrangement with Novartis Pharmaceutical and Medicare. Fortunately, it is working incredibly well once again. It has saved my life, twice and I'm leading a virtually normal, active life. Yes, it will return at some point, but considering I'm in my 10th year of metastatic castration-resistant stage 4 prostate cancer, it's wonderful to keep kicking the can down the road a couple of years with each round of treatments.
Stay informed, do your homework and don't give up.
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7 ReactionsI've been looking into immunology which has been improving good results for mCRPC. Might be something that will work for you.
What is your experience so far ?
I know a few people that have completed it and results vary. Some had the cancer stay away for a well over a year Other people have had it come back.
It is a known fact that 1/3 of the people get really good results 1/3 of the people get OK results and 1/3 of the people get no results at all.
One thing you should be aware of are Pluvicto genetic issues
RB1, PTen, TP53 are Pluvicto resistant
ATM & BRCA work better with Pluvicto
If you got a hereditary, genetic test You would know if you have any of these. Has it been offered to you by a doctor? You can get it done free with the below link, if you live in the United States. Do not check the box that you want your doctor involved or they won’t send you the kit until they get in contact with your doctor. It takes about three weeks to get the results and then a genetic counselor will call you.
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Prostatecancerpromise.org
You get a somatic Genetic test using blood or tissue to find out whether or not you have one of those genetic issues now. Things do change, and some people do get these genetic anomalies. Ask your doctor about this.
Has anyone finished all 6 treatments with Pluvicto? If so would you please share the outcome. How long has it been since completing the treatment?
Thank you for your reply
Jay
Thought and prayers🙏
Thank you for the encouragement. I pray it works for my husband.
Usually, the side effects are similar for the first three treatments. Some people can’t get past the first visit without serious side effects.
He will probably feel Back to normal a Couple of weeks before his August treatment
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