Can anyone share their experience with Pluvicto?

I was a clinical trial patient in original 2021-22 (Norvartis Pharmaceutical PSMA 617 Lu177), now Pluvicto, trial. It worked wonders for me. Eight or so years of other treatments prior to 2021 kicked the problem down the road, but no longer worked. Side effects were much less than chemo and other treatments I've received. If your situation is "to that stage" and you meet the requirements, I recommend it. Stay in touch

@michelegiger, this must be so hard to see you partner go through not one, but two tough cancers - like you said - a nightmare.

Did you and your husband decide to continue treatment and start Pluvicto? How are YOU doing?

We have consistently been told at Mayo Rochester and by our local medical oncologist that there is no approval in the US for more than six Pluvicto infusions, and my husband's Original Medicare plan and Anthem supplement are still saying they won't pay for additional infusions for that reason. You need to check to see if your specific coverage and plans somehow cover it, and your medical team would need to do the prior authorization, so check with them to see what they say.

Here is i’d answer, though it may not be really satisfactory.

Medicare may provide payment for a second round of Pluvicto, but coverage depends on your specific Medicare plan and whether the treatment is deemed medically necessary. Medicare does not have a National Coverage Determination (NCD) for Pluvicto, so coverage decisions may rely on Local Coverage Determinations (LCDs) or individual assessments. Additionally, prior authorization may be required, and the coding process can affect payment timelines.
To confirm coverage for a second round, consult your Medicare plan provider or the Medicare Coverage Database.

@foamhand May I ask how you got approved for an additional 6 doses?
My husband has been on a similar journey (12 years with bone Mets, doing his first round of Pluvitco Sep 23 - May 24). He had great results from Pluvitco. PSA’s starting to double each month & a second round is being discussed. He’s a little older, so on Medicare & I don’t believe they cover another round. Any insight would be appreciated

One next step could be chemo. After Pluvicto cabazitaxel and carboplatinum.

Ask your doctor.

My husband just celebrated 62-Diagnosed July '24 w Advanced (pelvic,Lymph, spine & scapula) completed 6 chem(completed 12/24), on Nubeqa and harmone injection every 3mos- PSA 1.02 2/25, Scan showed-not lit up in spine but still in Pelvic area
PSA today-1.66- Pain has moved from Pelvic to spine today!
Oncologist visit today-she is concerned- as pain has increased to spine and PSA has increased- she is recommending Pluvicto , and talks about 2-3 years life span..... I am trying to be a strong partner, this is the second cancer we are facing(Tonsil cancer in 2020) I cant stand to see the suffering, Hydrocodone brings some relief-last night he had a brutal nite- this is a nightmare.......

We are in similar situations. My Oncologist suggested we start a different Chemo which I hesitate due to how good I feel. I have a MRI for Pelvis and another for Femur scheduled for 4/07 and 4/15. Recent Bone Scan (3/03-04) was great, but with PSA increasing, I allowed "Jevtana" to be started on 3/26.
My Wife could no longer live with the Cancer and died by her own hand, which has reduced my self advocacy a bit, but I'm still in the game and will fight on. Pluvicto was a miracle for me. The treatment gave me another 18 months of myself back. I too had hoped to have a second round of Pluvicto. Fight on my Friend! Keep sharing findings........God Bless

My situation is similar. I completed 6 Pluvicto treatments Feb.2024 and psa stayed around .2 for 11 months.
Now psa is 4.6 which is doubling each month.
MO says I'm in uncharted waters and is still not sure of treatment options.
I can not afford the cost of re-treatment of Pluvicto and FDA has not approved beyond six treatments.
Anyone with treatment ideas is appreciated.

Some people have some major side effects from Pluvicto, most don’t. I have heard at least 5 people talk about their experience, In some cases they had to have more time between doses because of the side effects.

I saw a webinar where they discussed a person who lit up the Pet scan With metastasis from head to Legs. He had one Pluvicto Treatment and it almost cleared his pet scan, But his side effects were so bad that he could not take any more treatments

Be aware that it works really well for 33% of people OK for 33% of people and not at all for 33% of people.

If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer.

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant. I don’t know if these are the only hereditary changes that cause Pluvicto to work much better or more poorly.

If you have not had a hereditary test, I can give you the Website of a Study where you can get it for free.