Can anyone share their experience with Pluvicto?

Posted by vcash @vcash, Apr 22, 2024

My 85 year old dad has prostate cancer that has metastasized to his bones. Zytiga is no longer effective. He is considering Pluvicto. I would appreciate input from those who have used Pluvicto.

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Profile picture for kjbushur @kjbushur

Im happy to hear about your treatments. I would like to know how you got the insurance and supplies to cover the 2nd treatment. I finished my Pluvicto about 11 months ago. The hardest for me was the 3 days in quarantine, and the tiredness- which I was informed to take 10 MG of prednisone for tiredness.
We all must continue to battle this monster in us

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If you read the post/reply above, you will find the explanation that his first Pluvicto series was as a participant in a clinical trial. So for insurance purposes, his current s is his first.

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Profile picture for smc24 @smc24

In response to jay0013:
I was a Pluvicto clinical trial patient 2021-22 and responded remarkably well. It was a full 22 months after the final treatment before my PSA began to rise again and tumor growth was detected. The only side effects (other than being radioactive) were a day or two of feeling a little funky from the Lu-177 and some, but minor fatigue toward the end of the 6th treatment.
I am now repeating the 6 treatments (completed #4 of 6) via a special arrangement with Novartis Pharmaceutical and Medicare. Fortunately, it is working incredibly well once again. It has saved my life, twice and I'm leading a virtually normal, active life. Yes, it will return at some point, but considering I'm in my 10th year of metastatic castration-resistant stage 4 prostate cancer, it's wonderful to keep kicking the can down the road a couple of years with each round of treatments.
Stay informed, do your homework and don't give up.

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Im happy to hear about your treatments. I would like to know how you got the insurance and supplies to cover the 2nd treatment. I finished my Pluvicto about 11 months ago. The hardest for me was the 3 days in quarantine, and the tiredness- which I was informed to take 10 MG of prednisone for tiredness.
We all must continue to battle this monster in us

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Profile picture for newby82 @newby82

Hello I'm 82 and would like to know how you are doing and if you have survived this process. Hs the Pluvicto extended your life and has it been worth it? I pray you are still with us

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77 and going strong. I've not felt this good in over 23 years. You have nothing to loose. Good Luck...Gene

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Profile picture for newby82 @newby82

Hello I'm 82 and would like to know how you are doing and if you have survived this process. Hs the Pluvicto extended your life and has it been worth it? I pray you are still with us

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Be aware that it works really well for 33% of people OK for 33% of people and not at all for 33% of people. If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer.

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant.

Asking someone else if Pluvicto worked for them gives you no idea about how it could work for you.

Some people have some major side effects from Pluvicto, most don’t. I have heard at least 5 people talk about their experience, In some cases they had to have more time between doses because of the side effects.

I saw a webinar where they discussed a person who lit up the Pet scan With metastasis from head to Legs. He had one Pluvicto Treatment and it almost cleared his pet scan, But his side effects were so bad that he could not take any more treatments

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Is there anyone at ages 80 plus that can share their experience with Pluvicto? How have their kidneys fared during the process and the extension of life worthwhile ?? thanks for any input and help as I am considering pluvicto. PSA is 111 and I have hormone resistant metastatic PC. Thank you

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Profile picture for eugenelapietra1 @eugenelapietra1

76 years old in the same boat your dads in. Treatment #1 not bad at all, treatment #2 a little rough, Treatment #3 a total nightmare, Treatment #5 I didn't think I was going to survive. I don"t have a choice I'll take Treatment #5 and pray..........The rub is , everyone may have a different experience so I suggest gathering more testimonials . Pluvicto with all its unknowns is still the only game in town. If you decide to go through with the treatments you can contact me and I'll share with you some tips on how to make your dads trip easier. God Bless ,Gene

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Hello I'm 82 and would like to know how you are doing and if you have survived this process. Hs the Pluvicto extended your life and has it been worth it? I pray you are still with us

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Profile picture for happyhag @happyhag

I'm 79 and had stage 4 since 4/2019. After lupron still on and multiple oral rx"s I took achieved non detectable psa for about 4 years. Exhausted all rx's and had chemo for 5weeks. After a month off my psa started rising rapidly and started chemo again. After 3 weeks discontinued chemo and explored pluvicto and have had 2 treatments and will have my third in two weeks. Hopefully psa will decline. Stay tuned for the new results. HappyHag

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😍

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Profile picture for proftom2 @proftom2

Darolutamide (brand name Nubeqa) is an androgen receptor inhibitor used in the treatment of advanced prostate cancer. It works by blocking the effects of androgens (male hormones) that can stimulate the growth and spread of prostate cancer cells. So, so good.

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Would this be for metastatic to the bones?

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I'm 79 and had stage 4 since 4/2019. After lupron still on and multiple oral rx"s I took achieved non detectable psa for about 4 years. Exhausted all rx's and had chemo for 5weeks. After a month off my psa started rising rapidly and started chemo again. After 3 weeks discontinued chemo and explored pluvicto and have had 2 treatments and will have my third in two weeks. Hopefully psa will decline. Stay tuned for the new results. HappyHag

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Profile picture for happyhag @happyhag

What is Darolutamide

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Darolutamide (brand name Nubeqa) is an androgen receptor inhibitor used in the treatment of advanced prostate cancer. It works by blocking the effects of androgens (male hormones) that can stimulate the growth and spread of prostate cancer cells. So, so good.

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