Can anyone share their experience with Pluvicto?

I'm 83, had prostate removed on 2001, been on hormone therapy since then, also immune therapy, Xteva and now Pluvicto. I've had 3 injections with the only noticeable side effect was a dry mouth for about a week. After the 4 th injection the dry mouth has persisted for 3 weeks, not bad but taste is off a bit. I've been hiking between 5-6 miles a couple of times a week, kayaking and biking 20 miles.Somewhat fatigued but still able to participate. I read that the dry mouth could persist for awhile or even become permanent. I've been very fortunate my PSA went from 8 to .05 after 3 injections. Stopped the Xtandi after the 3 injection and next week will see what blood levels are. Since stopping Xtandi BP has dropped, hope to get off some BP meds.

I'm 83, had prostate removed on 2001, been on hormone therapy since then, also immune therapy, Xteva and now Pluvicto. I've had 3 injections with the only noticeable side effect was a dry mouth for about a week. After the 4 th injection the dry mouth has persisted for 3 weeks, not bad but taste is off a bit. I've been hiking between 5-6 miles a couple of times a week, kayaking and biking 20 miles.Somewhat fatigued but still able to participate. I read that the dry mouth could persist for awhile or even become permanent. I've been very fortunate my PSA went from 8 to .05 after 3 injections. Stopped the Xtandi after the 3 injection and next week will see what blood levels are. Since stopping Xtandi BP has dropped, hope to get off some BP meds.

I am 80 years old with stage IV prostate cancer which has metasasized throughout my bones. Been on various immunotherapy treatments for 3-4 years (most recent being Keytruda). All of them have run their course and are no longer effective.

I tried for several months to get the Pluvicto treatment but they didn't do it due to the FDA saying a person had to have had chemotherapy first. I elected to NOT have chemotherapy as it made no sense to me to kill off everything and hope that the good comes back faster than the bad.

Very recently, the manufacturer began to question the necessity for chemotherapy prior to Pluvicto and I am one of the first people to get Pluvicto without having had chemotherapy.

Pluvicto treatment protocol is an IV injection every six weeks for a total of six times. It is a heavy duty radiation treatment but it is NOT chemotherapy. It targets the cancer cells instead of the shotgun approach of chemotherapy.

I am halfway through my Pluvicto treatment. I have had three injections and will get number four in a week.

You will get detailed scans prior to the treatment, and the doctor will monitor your blood work closely and see how you are tolerating treatment before giving you the next injection.

After the injection, they turn you loose when your radiation level is three at a distance of three feet.

We joke that I "glow in the dark" after the injection but there is a certain amount of truth in that. I wanted this treatment for myself, but was concerned about "collateral damage" of radiation to anyone else around me. The official guidelines tell you to maintain a three foot distance from everyone for three days, and for seven days from pregnant women and small children (and by extension small animals like cats or dogs).

Every radioactive substance has a half-life and decays over time. I purchased a dosimeter (Geiger counter) from Amazon for about $100 to monitor my actual condition rather than simply going by their guidelines.

My personal experience is that, for me, the guidelines are not strict enough. I do not want to cause collateral radiation damage to anyone else, so monitor my radiation level daily at three feet, one and a half feet, and right next to my skin.

My personal protocol is to isolate myself for one week. I am alone in the bedroom, reading, binge watching Netflix, etc., leaving only briefly to get something to eat or go to the bathroom.

During week two I loosen up a bit, allowing brief contact such as a hug or a handshake, but no prolonged contact.

By the end of two weeks from my injection, my personal radiation level is down to zero at my skin, so I no longer have any danger of giving collateral radiation damage to anyone. At that point I resume sleeping in the same bed with my wife and have no issues with personal contact with others.

Everyone reacts differently to different treatments. I have tolerated it reasonably well. The worst side effect has been serious constipation. Also a moderate increase in fatigue.

I would like to get another scan now, halfway through treatment, but insurance won't pay for it. I will get another scan when all treatments are done so I will at least have a before and after reading on how effective (or ineffective) it has been.

Day 8? Can't even think anymore.
The pain has stabilized out to almost "undetectable".
However, last 2-3 days the fatigue has been EXTREME!.
Sleep almost all day, and all night.
When I do arise, VERY dizzy and wobbly.
Can't make it round trip to mailbox.
Used an old trick told me by my GP almost 40 years ago, gargle and swish with Hydrogen Peroxide. Two days, twice a day, took most of the coating off my tongue, and I have a lot of my taste back.

Gonna try going out today. No Oxycodone (test to see if that is in issue with fatigue) but 100mg Provigil, which did (surprisingly) NOTHING Sunday morning.

Have you heard of any that have had third stage kidney disease when starting treatment and will this take out your kidney's? How long did the side effects last? We are contemplating immunotherapy since Dad has a hard time with the thought of quarantine for three days and unsure he would be able to handle it.

Have you heard of any that have had third stage kidney disease when starting treatment and will this take out your kidney's? How long did the side effects last? We are contemplating immunotherapy since Dad has a hard time with the thought of quarantine for three days and unsure he would be able to handle it.

If I might ask, did you have any kidney disease when you began treatment?

Be aware that it works really well for 33% of people OK for 33% of people and not at all for 33% of people. If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer.

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant.

Asking someone else if Pluvicto worked for them gives you no idea about how it could work for you.

Some people have some major side effects from Pluvicto, most don’t. I have heard at least 5 people talk about their experience, In some cases they had to have more time between doses because of the side effects.

I saw a webinar where they discussed a person who lit up the Pet scan With metastasis from head to Legs. He had one Pluvicto Treatment and it almost cleared his pet scan, But his side effects were so bad that he could not take any more treatments

I am 86 and I will receive my 6th infusion 9/7/2025.
I have had very few side effects from Pluvicto. My PSA started out at 80 and now it is 2.6. Over the years I have had seed implants, hormone therapy, and Chemo, all with very little success.
I exercise every day and play golf twice a week.

I hope that you will respond to Pluvicto.

Willis Beavers

Is there anyone at ages 80 plus that can share their experience with Pluvicto? How have their kidneys fared during the process and the extension of life worthwhile ?? thanks for any input and help as I am considering pluvicto. PSA is 111 and I have hormone resistant metastatic PC. Thank you