Can anyone share their experience with Pluvicto?

Posted by vcash @vcash, Apr 22, 2024

My 85 year old dad has prostate cancer that has metastasized to his bones. Zytiga is no longer effective. He is considering Pluvicto. I would appreciate input from those who have used Pluvicto.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

What boat? Seahorse, 669.
Our local USSVI Chapter......draw a line between those who spent time near a hot rock and those on Diesels.....we are amazed at the differences in cancer occurrences. This past weekend, one of our DBF boys had his 100th. Two years ago I lost a good friend to PC....nuke on Nevada. 54.
I was a nose coner ET, Mk3/Mod6 SINS.

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Profile picture for scalecraft @scalecraft

I had to go back and review my nuclear protocols. Just to make sure. All those years on Nuke subs, at least we joked when we said "when they turn off the lights, I glow in the dark!"
Did you know with Pluvicto some folks promote Geiger counters and pocket dosimeters? A tad overkill with a short half-life.
Some folks say 30-day half-life, looking up Lutetium 177, half life is 6.65 days. Fits into 2-3 feet from children for 6-7 days.
Right now, with the majority of Docetaxel out of my system, been doing yard work. Been a long time.

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I am starting Pluvicto soon. I chuckled about the Nuke subs. That was my experience, too, about 50 years ago. All the best!

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Profile picture for proftom2 @proftom2

Semi-worked for me, just not in the way I hoped it would. I am a four Plavicto shot survivor. 4.6 Years since my advanced prostate cancer diagnosis. For 2.5 Years I was resistant, my PSA remained under control around 2 which means the ADT treatment was working. for the next 1.5 years my PSA started to rise, it was a slow rise. I started Pluvicto, 1 shot every 5 weeks, my PSA kept rising, and doubled, But, Pet-Scan indicated my tumors decreased in size and number. My oncologist liked that, but pulled me off Pluvicto to focus on treating my PSA. I start Darolutamide in a few view days.

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Thought the criteria was PSMA PET scan plus at let 4 ADT;s I did Scan plus Enzalutamide, 2 chemo's, Radium 223 and Abiraterone all of which failed PSA jumped 200 to 424 On referral to PMHC for LU 177else 6 months to live and on palliative care in Dec if I do not get this infusions I qualify for by all criteria Mind is very anxious 80 and feel great @northoftheborder

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Profile picture for scalecraft @scalecraft

Have to go look. Smaller than the Saccharin tablets we used to steal from Grandpa!

This is copied from my on-line med list:
"Take 0.5 tablets (2.5 mg) by mouth every 6 hours as needed for severe pain."
Try to cut one, you end up with powder, so I take a whole one.
Never done three in a day before.
Probably get away with two if I wash them down with Bourbon!
(I can say that because I HATE Bourbon!) Gets the Dr's attention anyway.

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So you’re taking 5 mg, I think it’s a smallest they make, The selection goes to 100 (or more?). That might relieve someone of consciousness.

I have a few of those 5’s leftover from having my knee replaced. They come in handy when you strain a muscle in the back in the gym and can’t move without pain. I find I have to be really careful in the gym, At 77 I can’t even increase the weights I am using by 10 pounds after three or four months without pulling something. The 5’s were worthless when I had my knee replaced.

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Have to go look. Smaller than the Saccharin tablets we used to steal from Grandpa!

This is copied from my on-line med list:
"Take 0.5 tablets (2.5 mg) by mouth every 6 hours as needed for severe pain."
Try to cut one, you end up with powder, so I take a whole one.
Never done three in a day before.
Probably get away with two if I wash them down with Bourbon!
(I can say that because I HATE Bourbon!) Gets the Dr's attention anyway.

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Profile picture for scalecraft @scalecraft

Day 4 ends now. 95 hours since infusion. Yesterday evening.....not bad at all. Can we hope?
Slept very well. 2 Aleve early, one Oxycodone before bed. Got up this morning........no pain.
We decided to keep Oxy on board all day, so one when I got up, I'll do one around 2 or 3 PM, last one before bed.
Tired and feel weak, addressed with 100mg Provigil this morning.
The clinic likes the scan results. Baseline. Next 2 scans will tell them.

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How many milligrams of oxy do you need to take?

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Day 4 ends now. 95 hours since infusion. Yesterday evening.....not bad at all. Can we hope?
Slept very well. 2 Aleve early, one Oxycodone before bed. Got up this morning........no pain.
We decided to keep Oxy on board all day, so one when I got up, I'll do one around 2 or 3 PM, last one before bed.
Tired and feel weak, addressed with 100mg Provigil this morning.
The clinic likes the scan results. Baseline. Next 2 scans will tell them.

REPLY

Semi-worked for me, just not in the way I hoped it would. I am a four Plavicto shot survivor. 4.6 Years since my advanced prostate cancer diagnosis. For 2.5 Years I was resistant, my PSA remained under control around 2 which means the ADT treatment was working. for the next 1.5 years my PSA started to rise, it was a slow rise. I started Pluvicto, 1 shot every 5 weeks, my PSA kept rising, and doubled, But, Pet-Scan indicated my tumors decreased in size and number. My oncologist liked that, but pulled me off Pluvicto to focus on treating my PSA. I start Darolutamide in a few view days.

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End of day 2 of session 1. Yesterday was the special scan. No results, yet.
Yesterday, so cold.....long sleeved shirt, light jacket, my big, thick comforter pulled up, my wool jacket over the top, heating pad.
Today, not cold. Go figure.
Bit of hip pain, lots of thigh pain, they say that's normal.
Nap time.

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I am 86 and will have my 4th Pluvicto infusion today 6/26/2025.
I had 9 treatments of Chemo. The PSA started out at
86 and got down to 7. Chemo was a real bitch. Then after 11 months the PSA was back up to 80 and I started Pluvicto. My PSA has dropped like a rock. 80 to 40, then 40 to 13 and now 13 to 5.5.
My side effects have been minimum. Way better than chemo.
I am one of the lucky ones that Pluvicto works on!

Willis Beavers

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