Can anyone share their experience with Pluvicto?

I was a clinical trial patient for Pluvicto Nov. 2021-May 2022, U. Of Chicago, standard 6 treatment 6 weeks apart. It was a last resort having been through most all standard protocol of surgeries, drugs, radiation, etc. I am stage 4 metastatic castration-resistant. At that time, data showed an typical 11-15 months life extension. My PSA dropped to almost undetectable, PET scans showed many tumors disappeared and others greatly reduced in size. I had a day or two of feeling mildly sick after each treatment, but very, very tolerable. It definitely kicked the can down the road.
Sept. 2024, PSA has shown slight rise and tumors are growing again. Having ruled out other options for one reason or another, many of which I have had, I have started the Pluvicto 6 treatments for the second time, completing the first (#7) three weeks ago. I follow the same post treatment isolation requirements due to the radiation. I had a week of mild upset stomach and annoying headache this time. In three weeks after the 2nd treatment (#8), I"ll have another PET scan to see how the tumors are doing. The PSA has stablized extremely low.
Thus, FOR ME, it saved my life once, so the doctors and I see this as the best option, and I'm doing it again. There is no published data on a patient going through these treatments twice.
Since Pluvicto finds and treats virtually every prostate cancer cell no mater were it is located in the body, I consider it an excellent option for a metastatic patient.

My dad - 80 yr old just started pluvicto. He has had one treatment, next one is in October.
You mention treatment gets rougher, may I ask what we can expect?
Also- did your psa go up anytime after treatment? His is up from 100 to 400.
Worried daughter - I appreciate anything information you are willing to share.

This is almost exactly my course. However, I start my first Pavo October 10 and my current PSA is just over 100. So I am concerned. I do live alone and no close family. So I am going at it solo. Which does make isolating myself much easier! LOL!!!
The constant pain is a problem and getting drugs here in central California is a problem as well. Our hospital has bought out most of the doctors and I think they want to be the number one hospital in the nation With the lowest opioid prescription rate.
But I am still able to get along OK and so I am thankful for that

You are getting very bad advice from your oncologist! Pluvicto has been approved by the FDA for several years for commercial use, after many years of clinical trials and peer-reviewed publications. Second, it is no longer a requirement to undergo chemotherapy before Pluvicto. You need to find a new oncologist ASAP. This one is either not current on prostate cancer treatments or doesn't want to bother getting up to date. Run, don't walk, away!

How much do you trust your oncologist?

He/she is just totally wrong in telling you the FDA doesn't have enough data to support it's use.

It USED to be that you had to have been treated with chemotherapy before qualifying for Pluvicto. That is no longer true. I just had my fifth Pluvicto treatment and I elected to not have chemotherapy.

There seems to be a hierarchy or tier to all the various types of cancer treatments available. A person newly diagnosed would not likely start out with Pluvicto. It's quite a ways down the line after several other, less drastic, avenues have been tried and have run their course.

It sounds like you might benefit from a second opinion from a different, more knowledgeable oncologist.

My experience with Pluvicto hasn’t begun yet because my Oncologist tells me the FDA doesn’t have enough data to support its use. I am told that I have to be treated
with chemotherapy before I qualify for Pluvicto.
Can someone help me make sense of this.
Thank you, Philnob

Completed all 6 Pluvicto immediately following 6 rounds of Docetaxel and carboplatin chemotherapy. The entire treatment was completed 8 weeks ago which all occurred in one year. This is a copy and paste from my choline PET scan this week which was 8 weeks after final Pluvicto:

Impression
Complete response to interval therapy. No definitive PSMA avid locally recurrent or metastatic disease.

Will return in 3 months for a PSMA scan.

Yes it is. I wish you the best of luck on your journey.

Yes and that’s great 🤗

Everybody makes their own decisions in this area. I choose to be much more conservative than the official guidelines. I came to that conclusion by monitoring my radiation levels on a regular basis and having a strong desire to NOT expose friends, loved ones, caregivers to unnecessary radiation. Driving home is fine, with an acceptable level of radiation exposure, although I do drive myself in order to not subject my wife to even that level of exposure. I just had treatment #5. My personal protocol protocol is to isolate myself for a week (not "three feet" like they say, but real isolation - sleep alone, no physical contact whatsoever), and then allow brief minimal contact (a hug, a handshake, being in the same room but still maintaining the three foot separation) for the second week after treatment. During that two weeks my radiation level continues to decline on a daily basis but I keep measuring it so that I know what my condition really is and how much radiation exposure a person would have from me by being in my proximity. At the end of two weeks my radiation level is minimal and I am back to full contact mode - sleep in same bed, kissing OK, snuggling on the couch watching Netflix, etc. We each make our own decisions in this area.