Can anyone share their experience with Pluvicto?

@michaelbryan6998
Michael, I hope that you've now had that fourth round of Pluvicto and the PSMA PET scan is now scheduled. I'm 77 years young, extensive mets, heart and other comorbidities, but taking it all as it comes and making the most of each day. Keep on keeping on.

79 years young with metastacized Prostate Cancer in my ribs & backbone. I also have IPF. I have been dealing with the cancer for 4 plus years. Chemo, ADT, direct radiation to the prostate, and now I"ve had two rounds of Pluvicto. Side effects: tiredness (to add to the effect from all the meds), dry mouth, increasing discomfort in my bowels, and a gnawing question about whether its working. My doc won't do another PSMA scan till after the 4th treatment which is frustrating - only way to know if its working or not. No pain from injection - hassle keeping distance from my wife and sleeping in separate rooms ( we like each other) but the tiredness increases and I wonder about other side effects. Thought it good news (at least for the drug company) that they have now approved it for use without chemo or ADT - the idea is great and hope its working and killing the cancer cells. Choose life, fight, fight, fight.

@jeffmarc
What if you have PTen and TP53 as well as ATM and BRCA?

Be aware that 1/3 of people have really good results from Pluvicto, 1/3 Respond OK and 1/3 get nothing from it.

Pluvicto genetic issues
RB1, PTen, TP53 are Pluvicto resistant
ATM & BRCA work better with Pluvicto

Have you had a hereditary Test or a somatic test? It would be good to have both before having Pluvicto So you can see if you have a genetic conflict.

Some people have some major side effects from Pluvicto, most don’t. I have heard at least 5 people talk about their experience, In some cases they had to have more time between doses because of the side effects.

I saw a webinar where they discussed a person who lit up the Pet scan With metastasis from head to Legs. He had one Pluvicto Treatment and it almost cleared his pet scan, But his side effects were so bad that he could not take any more treatments

To eugenelapietrial:
I believe your basic knowledge of the science and understanding of radiation is way off. Pluvicto uses beta particle. Although the exchange of bodily fluids should avoided for a predetermined time after a Pluvicto treatment, this includes exhaling water vapor, saliva, urine, sweat, etc. But, as with all radioactive particles, the particles of beta, gamma, etc. travels through the atmosphere. That's the basics of a sunburn (UV radiation), a medical x-ray or CT, scan, the atomic bomb, etc. I carry a small geiger counter with me after each Pluvicto treatment and can easily see and hear the radiation levels being emitted from my body. No bodily fluids required. The radioactive particles are emitted through the skin.

Ok Jeff, Please cite which clinical trail says that. You'd have to share your bodily fluids with your pet to transfer any radio active material to your pets .check that out.On this forum the info we share must be accurate.

Is there anyone at ages 80 plus that can share their experience with Pluvicto? How have their kidneys fared during the process and the extension of life worthwhile ?? thanks for any input and help as I am considering pluvicto. PSA is 111 and I have hormone resistant metastatic PC. Thank you

Ok Jeff, Please cite which clinical trail says that. You'd have to share your bodily fluids with your pet to transfer any radio active material to your pets .check that out.On this forum the info we share must be accurate.

Pets are just a susceptible to radiation as people, Maybe even more so since their bodies are so small.

It’s pretty obvious you never even did a search of the web about whether or not you should be near your pets after being treated with Pluvicto because that would Show you that what I said is accurate.