Can anyone share their experience with Pluvicto?

79, been thru chemo, ADT,and now one Pluvicto treatment. I also have IPF (Idiopathic Pulmonary Fibrosis) and had no real 'reactions' to the first Pluvicto injection.........but as the six week interval progressed, my level of 'tiredness' and lack of energy increased almost daily. I am not bedridden, but my breathing has become more labored and I have diminished energy (which was low pre-Pluvicto). My doc cancelled my 2nd Pluvicto treatment which was scheduled for 2 May (yesterday) based on my symptoms, and we all agree I need to see Pulmonologist for tests on lungs - question is has the Pluvicto accelerated the growth of the fibrosis? Complicated for sure, but I'm optimistic overall.

I am 86 and have been fighting prostate cancer since 2014.
My PSA started out at 80 and 6 weeks after the 1st treatment of Pluvicto it was 40. This is the best result I have ever had. Sure, beats the hell out of chemo. I will have the results of the 2nd treatment on May 12.
My only side effect I have had is diarrhea or constatation (not at the same time) during the 1st week after the infusion.
I am now back out on the golf course playing twice a week.

Best Wishes
Willis Beavers

You have to realize that Pluvicto is real successful for about 1/3 of people works OK for about 1/3 and it doesn’t work at all for 1/3 of people.

There are genetic issues, however. You want to make sure to get a hereditary genetic test as well as somatic genetic test to see if you have any of these genetic anomalies.

Pluvicto genetic issues
RB1, PTen, TP53 are Pluvicto resistant
ATM & BRCA work better with Pluvicto

Did you got a hereditary, genetic test. You can get the test free at the below site as long as you live in the United States. Don’t Pick the option for your doctor to be involved. They won’t send you the kit until they speak to your doctor. A geneticist will call you to discuss the results in abouft three weeks.

Prostatecancerpromise.org

Older gent here who has progressed through chemo, standard radiation, a variety of scans (MRI, PET, etc) and I just have my first Pluvicto injection at the beginning of May '25. Looking for folks who might be able to shed light on how the Pluvicto injections have worked/not worked and what side effects you've had to work through. I'm on multiple opioids and a steroid to control pain—as long as I maintain the regimen, things seem reasonable. Lose track of where I am in the day and things go sideways rapidly.

Thanks

I was a clinical trial patient in original 2021-22 (Norvartis Pharmaceutical PSMA 617 Lu177), now Pluvicto, trial. It worked wonders for me. Eight or so years of other treatments prior to 2021 kicked the problem down the road, but no longer worked. Side effects were much less than chemo and other treatments I've received. If your situation is "to that stage" and you meet the requirements, I recommend it. Stay in touch

@michelegiger, this must be so hard to see you partner go through not one, but two tough cancers - like you said - a nightmare.

Did you and your husband decide to continue treatment and start Pluvicto? How are YOU doing?

We have consistently been told at Mayo Rochester and by our local medical oncologist that there is no approval in the US for more than six Pluvicto infusions, and my husband's Original Medicare plan and Anthem supplement are still saying they won't pay for additional infusions for that reason. You need to check to see if your specific coverage and plans somehow cover it, and your medical team would need to do the prior authorization, so check with them to see what they say.

Here is i’d answer, though it may not be really satisfactory.

Medicare may provide payment for a second round of Pluvicto, but coverage depends on your specific Medicare plan and whether the treatment is deemed medically necessary. Medicare does not have a National Coverage Determination (NCD) for Pluvicto, so coverage decisions may rely on Local Coverage Determinations (LCDs) or individual assessments. Additionally, prior authorization may be required, and the coding process can affect payment timelines.
To confirm coverage for a second round, consult your Medicare plan provider or the Medicare Coverage Database.

@foamhand May I ask how you got approved for an additional 6 doses?
My husband has been on a similar journey (12 years with bone Mets, doing his first round of Pluvitco Sep 23 - May 24). He had great results from Pluvitco. PSA’s starting to double each month & a second round is being discussed. He’s a little older, so on Medicare & I don’t believe they cover another round. Any insight would be appreciated

One next step could be chemo. After Pluvicto cabazitaxel and carboplatinum.

Ask your doctor.