Can anyone share their experience with Pluvicto?

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Would this be for metastatic to the bones?

I'm 79 and had stage 4 since 4/2019. After lupron still on and multiple oral rx"s I took achieved non detectable psa for about 4 years. Exhausted all rx's and had chemo for 5weeks. After a month off my psa started rising rapidly and started chemo again. After 3 weeks discontinued chemo and explored pluvicto and have had 2 treatments and will have my third in two weeks. Hopefully psa will decline. Stay tuned for the new results. HappyHag

Darolutamide (brand name Nubeqa) is an androgen receptor inhibitor used in the treatment of advanced prostate cancer. It works by blocking the effects of androgens (male hormones) that can stimulate the growth and spread of prostate cancer cells. So, so good.

There are four different ARSI. Zytiga, apalutamide Enzalutamide and Darolutamide. If you have Prostate cancer that has already metastasized or ADT is no longer keeping your PSA down then you usually get on an ARSI.

Darolutamide is the ARSI with the least amount of side effects. I’ve been on it for 20 months and it’s kept my PSA undetectable even though I’ve had prostate cancer for 15 years.

I know at least a dozen other people that are using it some without anything else.

I did take Zytiga For 2 1/2 years. It kept my PSA down, but I was only undetectable for one month. I then switched over because Zytiga caused me heart problems.

If you need to be on one of those four drugs, I have mentioned than the easiest one on your body is Darolutamide.

What is Darolutamide

It took a day before I felt any change and then rebounded back to normal in 3 or so days after each treatment. I could tell I was a little more fatigued after treatments 5 and 6, but it didn't interfere with my daily routine. I made sure to eat well, get a night's sleep and sometimes took a short nap during the day. Overall, for me, it wasn't a big deal. I hope you do well, too.

Thank you for sharing. Husband started first Pluvicto treatment and is only suffering from fatigue. From your comments it sounds that as the treatments continue, the side effects get worse. Is that true?

In response to jay0013:
I was a Pluvicto clinical trial patient 2021-22 and responded remarkably well. It was a full 22 months after the final treatment before my PSA began to rise again and tumor growth was detected. The only side effects (other than being radioactive) were a day or two of feeling a little funky from the Lu-177 and some, but minor fatigue toward the end of the 6th treatment.
I am now repeating the 6 treatments (completed #4 of 6) via a special arrangement with Novartis Pharmaceutical and Medicare. Fortunately, it is working incredibly well once again. It has saved my life, twice and I'm leading a virtually normal, active life. Yes, it will return at some point, but considering I'm in my 10th year of metastatic castration-resistant stage 4 prostate cancer, it's wonderful to keep kicking the can down the road a couple of years with each round of treatments.
Stay informed, do your homework and don't give up.

I've been looking into immunology which has been improving good results for mCRPC. Might be something that will work for you.