Cabometyx (cabozantinib), pain in feet

Posted by zacharycat @zacharycat, Jan 17 2:46pm

I have been taking cabometyx (40 mg/day) since June. Many side effects, and recently foot pain has gotten worse. Last night I woke up in severe pain, especially on soles of feet, and stiffness that kept me awake. I put on some skin moisturizer and was eventually able to get back to sleep, but walking this morning was painful.
Anyone else have this condition and how are you managing it? I read that steroid creams (like clobetasol) or topical analgesics can help.

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volene | @volene | Jan 18 2:07pm

I got blisters on my feet, and Clobetasol cream along with Diclofenac sodium topical gel has helped my feet. I also wear shoes in the house for further protection.

kenc | @kenc | Jan 19 2:09pm

I use an arthritis cream, which is working.

djchambers | @djchambers | Jan 20 11:41am

I have had feeling in soles of my feet that I was walking on spikes. The oncologist office said that’s neuropathy. That was second cap/ tem cycle. Luckily it went away after I finished that round. And it hasn’t yet come back.
I generally exfoliate my feet every day and moisture as the instructions said to do with these chemo pills.

djchambers | @djchambers | Jan 21 12:54pm

Update—I have neuropathy back again today. I took only four temo doses this time per oncologist’s recommendation. Last night was last one. One more dose today of cap and I finish this cycle. Yay!

zacharycat | @zacharycat | Jan 21 1:29pm

Last couple days have also had diarrhea (possibly flu or virus). Skipped the morning dose and also rescheduled an oncologist appointment. I got the impression they don't want infectious people around other cancer patients.

2026sewabit | @2026sewabit | Feb 15 11:21pm

I’m on Cabometyx 20 mg daily & immunotherapy. Had a corn on left foot which healed using corn bandages for two weeks around mid December. Now on same foot have two corns side by side on same foot, which is even more painful. This time around using a “corn stick” with bandages. This corn stick is the same size lip balm. When I asked PA unrelated to Mayo Clinic I was told my first time experience with feet corns had no correlation to my cancer treatment meds. Has anyone experienced “corns” on their feet?

ozzie0101 | @ozzie0101 | Feb 19 12:04am

In reply to @2026sewabit "I’m on Cabometyx 20 mg daily & immunotherapy. Had a corn on left foot which healed..." + (show)

Oh golly gosh yes. Corns, corns and then some more corns and friction calluses.
First started when I was on Lenvatanib,
but they weren't painful so the podiatrist would just take them out but now...I am on daily Cabozantanib 40mg and they can be so painful at times. I tried to fix it up myself with inner soles, making my own real sheepskin inner soles, wider shoes, cutting little holes in my inner soles where the corns are to make a place for them, but sometimes they are so painful.
Have been to Podiatrist 4 times in 4 months to have them debraded, but they grow & pain comes back.
He says I will need Orthotics $$$$$$$.