1. < Breast Cancer

Biopsy/Pathology changed to triple negative while on treatment

Posted by ampeltekian @ampeltekian, Apr 26, 2023

I had a biopsy 5 months ago. The outcome was ER/PR + HER2 -ve.

I was on Kisqali/Femara treatment for 5 cycles which gave mixed results and the Oncologist ordered a new Biopsy.

The results show that the tumor has transformed to Triple Negative PD L1

Interested in more discussions like this? Go to the Breast Cancer Support Group.

windyshores | @windyshores | Apr 26, 2023

Is your cancer stage 4?

REPLY
ampeltekian | @ampeltekian | Apr 26, 2023

Yes. It is metastatic.

The point I was trying to make was if the objective of these treatments is to eliminate Estrogen clearly ER will be negative

REPLY
1 reply
Zebra | @californiazebra | Apr 27, 2023
In reply to @ampeltekian "Yes. It is metastatic. The point I was trying to make was if the objective of..." + (show)
@ampeltekian

Yes. It is metastatic.

The point I was trying to make was if the objective of these treatments is to eliminate Estrogen clearly ER will be negative

Jump to this post

I have ER/PR+ HER2- breast cancer. My understanding is ER+ breast cancer means the cancer cells have estrogen receptors that can bind with estrogen to promote cancer cell growth. Even if the estrogen disappears in the body due to Femara, the cells could still have the estrogen receptors making it ER+. Could your breast cancer have randomly mutated into triple negative? I take Kisqali (inhibits CDK 4/6 proteins that help cancer cells divide) and Letrozole (reduces the amount of estrogen produced in the body). It's been working for me for over 2 years. I haven't had another biopsy since we removed the cancer down to a level of not being able to view it on scans. It's just a wait and see for me. My cancer is super aggressive this time so let's hope the meds keep working and my cancer doesn't further mutate. Best of luck to you.

REPLY
Please sign in or register to post a reply.