Thoughts on the best approach for ATM mutation treatment?

This is what AI says :

"the DNA repair gene ATM has changed within the tumor cells, making them less able to fix DNA damage, often leading to more aggressive cancer and potentially making it sensitive to targeted treatments like PARP inhibitors, such as olaparib, which exploit this weakness for therapy. This mutation, found in 5-8% of castration-resistant cases, indicates poor DNA repair, affects metabolism (enhancing sugar use), and is a key biomarker for specific drug eligibility. "

My husband has 3 somatic mutations and when we asked MO about them he gave us no particular or in depth explanation about their implications. I hope that you will get good insight from your doctors.

Wishing you all the best : )

I included a number of thoughts about the ATM treatment in the other Message you posted.

There really isn’t any treatment for ATM, But that combination treatment with PARP may be an answer. I discussed it in the other message.

For those interested, here is an article on some research done on ATM gene mutations by the NIH. It is a bit technical.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10240520/

@dinu, you might appreciate this article from Mayo Clinic
- Prostate cancer: Family history, genetics and your risk https://cancerblog.mayoclinic.org/2024/09/04/prostate-cancer-family-history-genetics-and-your-risk/

Having the ATM mutation increases one's risk for breast, prostate, and pancreatic cancers. Knowing your family’s cancer history and information obtained from your genetic testing can also be important for other family members who may also want to do their own screening tests based on your results. Has your cancer team suggested that other family members seek genetic counselling?

Some genetic mutations respond better to targeted drugs and specific treatments. What course of treatment was recommended for you?

@colleenyoung
hi Colleen, thank you for the article.
The reason i can screen in the first place is because my father had PCa, and my mother had Breast and Stomach cancer. Both of them went through treatment and are cancer free now.

My brother will get himself tested in the coming year.
If you read my timeline, i started with Bicalutamide 40mg immediately after the biopsy positive results with a PSA of 180. 1 moth later after the PSMA tests came back (T3b, Gleason 9 (4+5), 9 of 12 cores affected) the urologist put me on Lupron 3 month depot.
After 1st month PSA dropped to 4, however 2 month results showed the PSA rising back to 11.
Right now i got switched to Degarelix 1 month depot.
I have a PSMA scheduled in February, but i am trying to get an appointment sooner, in January.
The idea is to do RARP in February.
Afterwards, it will probably be followed up with some RT and adjuvant.

@dinu

Hello Bro dinu!

\\After 1st month PSA dropped to 4, however 2 month results showed the PSA rising back to 11.

How do testosterone levels change?