ATM mutation

This is what AI says :

"the DNA repair gene ATM has changed within the tumor cells, making them less able to fix DNA damage, often leading to more aggressive cancer and potentially making it sensitive to targeted treatments like PARP inhibitors, such as olaparib, which exploit this weakness for therapy. This mutation, found in 5-8% of castration-resistant cases, indicates poor DNA repair, affects metabolism (enhancing sugar use), and is a key biomarker for specific drug eligibility. "

My husband has 3 somatic mutations and when we asked MO about them he gave us no particular or in depth explanation about their implications. I hope that you will get good insight from your doctors.

Wishing you all the best : )

I included a number of thoughts about the ATM treatment in the other Message you posted.

There really isn’t any treatment for ATM, But that combination treatment with PARP may be an answer. I discussed it in the other message.