Aromatose inhibitors and osteonecrosis of the jaw

I have not heard of osteonecrosis from AI. That being said since bone strengthening drug are frequently given at the same time, the timing would be suspicious. Here is an article from Sloan Kettering about this topic.
https://www.mskcc.org/cancer-care/patient-education/osteonecrosis-jaw-onj

Have you had bisphosphonates? Are you having jaw trouble?

https://pubmed.ncbi.nlm.nih.gov/32270377/ right now I am ok. I do not take biophosphates. I have friends that got this from taking arimatose inhibitors and therefore I am curious if symptoms/problems are evident early on.

I've never heard of aromatase inhibitors causing osteonecrosis. The AIs prevent the production of estrogen, thereby depleting estrogen from the body. Estrogen plays a role in bone-cell turnover and replacement so, depleting it increases the rate of loss of bone density. Oncologists who put women (and maybe male as wee?) patients, especially those with or near osteoporosis, tend to put the patient on meds to try your slow down that rate of loss. The bisphosphonates were the first drugs prescribed for that but one not-common side effect they cause is osteonecrosis of the jaw. In the medical literature it's named BRONJ, bisphosphonate related osteonecrosis of the jaw. The non-bisphosphonate Proplia has been found to result in it as well now.

So the cause of BRONJ is the bisphosponates (Fosamax, Bonnie and several others) taken to prevent or slow down the negative effects on bone density from estrogen depletion, which is the goal of the AIs, in an effort to stave off estrogen-fueled cancers.

The folks who published this paper concluded that it was a false positive, and that the algorithm was picking them up because of the bisphosphonates being given in conjunction with the AI. It was in the paper just further down and hidden a bunch of medical lingo. I hope this eases your concerns.

I looked at the article you linked and it says that the signal associating the three aromatase inhibitors was a 'false positive.' Meaning there us no direct link between the drugs and ONJ. If I understood that you gave friends with the condition, and taking AIs, it's likely they were also taking bisphosphonates as an auxiliary drug.

Oops, I belatedly realized you'd already answered this, Chris.