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Apa-RP Study: ADT + Apalutamide (Erleada)
We all spend considerable time and effort looking at pCA information. One of the studies that keeps rising to the surface, for me, is this one:
https://www.targetedonc.com/view/apalutamide-adt-delivers-100-rfs-at-2-years-in-high-risk-prostate-cancer
Specifically, wow, what a response - 100% without BCR! That is remarkable. I feel like this will be a standard of care, but we are not there yet. Just wondering what others think or have experienced. Thanks.
Steve
"Treatment with apalutamide (Erleada) and androgen deprivation therapy (ADT) led to a biochemical recurrence (BCR)-free survival rate of 100% (90% CI, 93.0-100.0) at 24 months among patients with high-risk localized prostate cancer who have undergone radical prostatectomy (RP)."
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You said it - WOW!! Only drugs and NO radiation and many men had Gleason 9 and 10? Unbelievable results even after just 24 months. I guess we’ll have to wait for the 5 yr numbers but it’s still pretty amazing. Great find!
Phil
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Hug
2 ReactionsBut ... Were they counting 2 years AFTER the end of this treatment, or one year of treatment itself was included in those "2 years" of no BCR ?
I took it to mean 24 months AFTER completion of treatment ( which was 12 cycles of 28 days each - or one year).
However, if you read the article multiple times it becomes less clear.
I do see your point, But what would be the sense of publishing a paper declaring 24 months BCR free if one of those years included actual treatment?
Since BCR can only be measured by change in PSA, would the endpoint be valid if the participants were still on ADT which drastically lowers PSA?
The wording is ambiguous to say the least. From my own experience with ADT, my PSA dropped to < .05 - and that was even before radiation. But My RO couldn’t tell me I was BCR free at that point since stopping the ADT would have sent the PSA upwards again and only the combo with radiation ‘could’ grant me remission…for a while….I hope🤞
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Hug
2 ReactionsI guess we will know it in couple of years ... May the prostate gods have mercy on us all /\ *sigh
Wouldn't it be great though : ))) ? But I am sure it is just matter of time till scientists find the magic combo and are able to eradicate this beast at ANY stage : ) . So much is already discovered in the past few years !
Phil - am sending you healing vibes and I am sure that your treatment was successful - you have great doctors and are in excellent hands, but if only you could stop drinking milk - JK JK JK !!!! Have to tease you little bit in hopes to make you laugh XP, ha ha.
But, I am not joking about sending healing vibes and best wishes your way < 3. You will beat this thing - I have no doubts about it !!!
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4 Reactions1 year according to this:
https://www.jnjmedicalconnect.com/products/erleada/medical-content/erleada-apa-rp-study
"Primary endpoint: BCR-free survival at 24 months (12 months after completion of planned treatment)"
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Hug
1 ReactionCan’t get the article - trapped in an endless loop of J&J crap!
Put it in a private/incognito tab and say you are a healthcare professional when prompted. That's what I did.
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Hug
1 ReactionYup, they explain it in more detail in this article that you posted. It’s very strange to me however, that they include the first 12 months of treatment as BCR-free survival; I’ve never read a study like that, have you?
I could see it if they were talking about time to castrate resistance while on ADT and apalutamide but it is simply BCR…..go figure. Thanks!
Phil
Surfer Marcellus : "Something is rotten in the state of Denmark," ... XP
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