Anyone get the Decipher test: RNA Tumor RNA Expression Analysis?

Posted by rabaldwinjr @rabaldwinjr, Mar 4 10:50am

Anyone get the Decipher genomic test, and specifcally, the "RNA Tumor RNA Expression Analysis?" How are your docs using that info for determing treatment? I'm Gleason 6 (3+3) Active Surveillance.

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gently | @gently | Mar 4 11:49am

rabadwinjr, I've only seen it used to determine if ADT should be recommended. There is lots of information on the genetics of the tumor if you are interested in how activated your immune system and more. But you have to ask for the grid. Most medical offices don't receive the entire grid, but you can request it through Decipher.

handera | @handera | Mar 4 3:45pm

I called and got my Decipher GRID report for my low volume 3+4 Gleason PCa.

It was the primary piece of scientific evidence, from the cancer cells taken in my biopsy, that helped me to confidently choose AS.

It’s been 17 months since I was diagnosed and everything has been moving in the right direction ever since…glad I chose AS.

rabaldwinjr | @rabaldwinjr | Mar 4 7:18pm

My interest was the lower right section pertaining to "neuroendocrine-like." Anyone have experience in that area?

gently | @gently | Mar 4 9:36pm

In reply to @rabaldwinjr "My interest was the lower right section pertaining to "neuroendocrine-like." Anyone have experience in that area?" + (show)

No experience here but this is exactly the type of information Decipher will help with.
"In general, NEPC differ from conventional PCa histologically by presence of neuroendocrine cells which do not express generic PCa markers like AR, P501S, PSMA, PSAP and PSA but characteristically expresses neuroendocrine markers such as chromogranin A, synaptophysin, CD56, and NSE."
It might mean that your cancer has the potential to be more aggressive.
"The Decipher Genomic Resource Information Database (GRID) is a novel research tool that captures 1.4 million marker expressions per patihttps://decipherbio.com/decipher-prostate/physicians/decipher-grid/ent and may facilitate precision-guided, individualized care to patients with prostate cancer."
https://decipherbio.com/decipher-prostate/physicians/decipher-grid/ 18 minutes into the video there is a sample grid--the portion most patients never see.
"Neuroindocrine [LIKE]" means that it it has similar tissue, but still may not be a fully neuroendocrine cancer.