Anyone else experiencing B6 toxic peripheral neuropathy?

Great question! In the NIH National Library of Medicine (ncbi.nim.nih.gov. Vitamin B Toxicity): "Sensory neuropathy usually develops at doses of pyridoxine (Vitamin B6) above 1000mg. There are some case reports of sensory neuropathy at doses less than 500mg per day in patients taking supplements for months. However none of the studies had nerve damage at a daily intake below 200mg of pyridoxine per day. "
Your question was timely for me because B6 is one of the B vitamins typically mentioned as important for individuals suffering from neuropathy. I had just ordered B6 that lists as a supplemental fact:
VITAMIN B6 (as pyridoxine HCI) 100mg. 5,882% Daily Value (based on 2,000 calorie diet).
I was ready to toss this out when I began reading the article until I saw that this level is "supposedly" safe.
What is your story? Thank you!
Mike

Well my eyes have been opened to this. I took Twinlabs Stress B complex daily for well over 15 years. It has 40 mg of pyridoxine HCL. I am homozygous for A1298C mutation on gene MTHFR. This has resulted in b vitamin methylation issues. My B6 level was 248 nmol! I have been dealing with distal neuropathy for 8 years, in legs. My story is very complicated, but lets just say this was very much likely the main reason for my overall decline the last 5 years. BE CAREFUL WITH B6 supplements!!
There are cases reported in some taking 25 mg/day chronically. It builds up, especially if you have any methylation issues. The daily rec'd allowance is VERY high in the US compared to other (albeit, smarter) countries. They are ahead of the game.