Anyone on Pluvicto (Lu 177), a new drug for prostate cancer?

Posted by dedehans @dedehans, Aug 20, 2022

My close friend has had Pluvecto treatment suggested to him by oncologists. It is relatively new, having been approved by the FDA in March 2022. Have any of you been given this drug? I have read it is radioactive material and patient needs to stay away 6 ft from others for at least 3 days so as not to contaminate them. He has not yet decided whether to take the treatment or not as he is feeling awful enough as is.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

I will receive my 5th treatment today. I am also on Lupron and zytiga and still responsive to ADT. Dozens of Mets in spine and pelvis. Psa now undetectable and tumors are improved and prostate shrank. I am part of a clinical trial. Diagnosed last summer 2022.

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@colleenyoung

All invited to the June 14, prostate cancer support group at noon Central time. You can join in person in Rochester, MN or participate online via Zoom

Dave Hulbert, prostate cancer survivor and wellness coach, is the guest speaker who will present, “My Journey with Advanced Prostate Cancer.” Dave has a compelling reason to keep up on the latest in prostate cancer treatments. He will share much of that with us, including his experience with Pluvicto, the new theranostics agent labeled with Lu-177.

See details here: https://connect.mayoclinic.org/event/prostate-cancer-support-group-7/

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Is there anywhere I can read about? What discussions happened there I’m interested in pluvicto info thanks Dave

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I might be going on pluvicto depending on my test results I would like to hear from people who have been on it and how it worked in the side effects. Thanks. Dave

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Stonewalker, everyone who has cancer wonders and worries about how can the system help when you are in pain and you are very uncomfortable, particularly when you are in late stage cancer. If I were you, I would speak to my doctors and their professional staff, with my family present, about what they can do to help manage this stage of the cancer battle. There are several civilized ways to handle your present situation and your medical staff and family can help you decide which one would be best for you. I have thought out what I would want if and when I got to your stage, however, those decisions are very difficult and I am sure that I would need family and professional help in the decision making process. Good luck to you and your family.

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@dwpoole

Currently being treated in clinical trial for stage 4 PC thst is still responsive to hormone treatment I’ve had four doses so far with side effects of dry mouth. Lipase has shot up from treatment but plan to finish all six doses. Psa is now undetectable. It’s hard to know if hormone therapy is responsible for remission or pluvicto. Been in treatment about 5-6 months and started with psa of 84 and numerous Mets to bones.

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I just had my second round of Pluvicto and it is not working for me. We're not going to continue. My biggest problem is the increase in the size of my prostate has caused problems with peeing and pooping. A lot of problems. I seem to be almost totally blocked off from pooping. Dr will not consider a prostatectomy at this stage since he says they always end up badly. He give me maybe three months. Honestly, three months of this is hell. I'm not sure I'm willing to wait it out.
I wish all my fellow sufferers and their caregivers good health and happiness as well as miracle cures. God bless you all.

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All invited to the June 14, prostate cancer support group at noon Central time. You can join in person in Rochester, MN or participate online via Zoom

Dave Hulbert, prostate cancer survivor and wellness coach, is the guest speaker who will present, “My Journey with Advanced Prostate Cancer.” Dave has a compelling reason to keep up on the latest in prostate cancer treatments. He will share much of that with us, including his experience with Pluvicto, the new theranostics agent labeled with Lu-177.

See details here: https://connect.mayoclinic.org/event/prostate-cancer-support-group-7/

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Yes. I’m at md Anderson in houston. Comparison scans showed fewer lesions with less uptake. More scans later this month. All good news so far.

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@dwpoole

Currently being treated in clinical trial for stage 4 PC thst is still responsive to hormone treatment I’ve had four doses so far with side effects of dry mouth. Lipase has shot up from treatment but plan to finish all six doses. Psa is now undetectable. It’s hard to know if hormone therapy is responsible for remission or pluvicto. Been in treatment about 5-6 months and started with psa of 84 and numerous Mets to bones.

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Have you had scans? Mayo did scans after 2, 4, and 6th treatment.

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Currently being treated in clinical trial for stage 4 PC thst is still responsive to hormone treatment I’ve had four doses so far with side effects of dry mouth. Lipase has shot up from treatment but plan to finish all six doses. Psa is now undetectable. It’s hard to know if hormone therapy is responsible for remission or pluvicto. Been in treatment about 5-6 months and started with psa of 84 and numerous Mets to bones.

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@leebeth

My husband received Pluvicto yesterday, with post treatment scan this morning. Top notch team here at Rochester Mayo. We could not be more impressed.
The rules and restrictions have eased somewhat; as safety monitoring has indicated that it is safe to do so.
Primarily, precautions need to be observed around pregnant women and children under 10.
Precautions continue with bodily fluids, closing toilet lid before flushing twice, etc.
It really isn’t inconvenient. At home, he will just use a different bathroom.
He tolerated it just fine, with no fatigue or other side effects at this point.
He is drinking copious quantities of water, as instructed.
We are very hopeful.
Best of luck to you, and if I can help in any other way, be sure to let me know.

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I have received 4 doses of pluvicto in a clinical trial. I am also on hormone therapy snd am responsive. Started treatment December 2022 for my stage 4 pc. Currently psa is undetectable. I have bad dry mouth and fatigue but will finish clinical trial

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