1. < Prostate Cancer

Anyone on Pluvicto (Lu 177), a new drug for prostate cancer?

Posted by dedehans @dedehans, Aug 20, 2022

My close friend has had Pluvecto treatment suggested to him by oncologists. It is relatively new, having been approved by the FDA in March 2022. Have any of you been given this drug? I have read it is radioactive material and patient needs to stay away 6 ft from others for at least 3 days so as not to contaminate them. He has not yet decided whether to take the treatment or not as he is feeling awful enough as is.

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ncoic | @ncoic | Oct 10, 2022
In reply to @patgwenn "I saw your comment regarding your friend and looking at pluvicto. My husband just started on..." + (show)
@patgwenn

I saw your comment regarding your friend and looking at pluvicto. My husband just started on this Aug 25 at Duke. In an abundance of caution we are sleeping in different rooms through his treatment. He is having a side effect that’s not listed in trial participants which is a horrid itchy rash that’s been impervious to Benadryl or OTC cortisone cream. Doctors are baffled as it’s not a side effect listed.

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Thanks for mentioning the rash. I will be starting Pluvicto in about 3weeks and knew of other possible side effects. At my first nuclear medicine consultation I will be discussing side effects and will bring up the possibility of a rash

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dd2312 | @dd2312 | Sep 13, 2022

This treatment and many other topics were part of the livestream of the Prostate Cancer Research Institute 2022 which happened last weekend. They are on YouTube, at


Many excellent talks occurred over 2 days and I highly recommend them.

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patgwenn | @patgwenn | Sep 11, 2022
In reply to @dedehans "Thank you Colleen. I shall wait and see future responses. My friend is in the decision..." + (show)
@dedehans

Thank you Colleen. I shall wait and see future responses. My friend is in the decision mode now. The cancer has metastisized widely and this may be a hope for him. I will post here if I hear he is going to try it.

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I saw your comment regarding your friend and looking at pluvicto. My husband just started on this Aug 25 at Duke. In an abundance of caution we are sleeping in different rooms through his treatment. He is having a side effect that’s not listed in trial participants which is a horrid itchy rash that’s been impervious to Benadryl or OTC cortisone cream. Doctors are baffled as it’s not a side effect listed.

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1 reply
dedehans | @dedehans | Sep 11, 2022
In reply to @norske46 "@dedehans , I am so sorry to hear about your friend 's deteriorated condition. I hope..." + (show)
@norske46

@dedehans , I am so sorry to hear about your friend 's deteriorated condition. I hope hospice care can help alleviate his pain and gain him some comfort and peace. Our prayers are with you and him. Good luck.

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Thank you. On my way for a short visit. I will keep reading this thread and wish all of you good things.

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norske46 | @norske46 | Sep 11, 2022

@dedehans , I am so sorry to hear about your friend 's deteriorated condition. I hope hospice care can help alleviate his pain and gain him some comfort and peace. Our prayers are with you and him. Good luck.

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dedehans | @dedehans | Sep 11, 2022

My friend's prostate cancer is too advanced in his body (bones, soft tissues), and he has been determined to be too weak for the pluvicto treatment by his oncology team. He is electing to do hospice as he is in terrible pain.

I thank you all for your helpful and encouraging posts on this topic I started. Hugs to all.

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norske46 | @norske46 | Sep 10, 2022

https://kcci.com/article/iowa-man-with-advanced-prostate-cancer-finds-hope-in-new-treatment-at-des-moines-hospital/41111092
While this not a particularly helpful report on the clinical side of Lu177, it is a testimonial of one patient's experience with the treatment. I hope it is helpful for at least some who follow this discussion topic.

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leebeth | @leebeth | Sep 2, 2022

The biopsy is your best bet for sure. Sounds like you have a knowledgeable team and are in good hands.

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rso | @rso | Sep 2, 2022
In reply to @leebeth "Yes, be grateful your physician looked for this. Seriously bad outcomes can occur if this is..." + (show)
@leebeth

Yes, be grateful your physician looked for this. Seriously bad outcomes can occur if this is missed.
Praying that the correct treatment is found for you.

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It seems that Pluvitco is used for those who have bone metastasis which I do not, well at least yet at this rate. Hopefully it won't progress to 5hst before my second biopsy is performed and resulted. New tumors have been showing and progressing which is very worrisome. Mismatched lesions I guess which the doc can't definitely say are prostate cancer. Such a crazy time.

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leebeth | @leebeth | Sep 2, 2022
In reply to @rso "Thank you for that term. I now have a better understanding of why I was taken..." + (show)
@rso

Thank you for that term. I now have a better understanding of why I was taken down a dead end road. All good intentions.
https://jnm.snmjournals.org/content/63/6/812.full

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Yes, be grateful your physician looked for this. Seriously bad outcomes can occur if this is missed.
Praying that the correct treatment is found for you.

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