Anyone on Pluvicto (Lu 177), a new drug for prostate cancer?

Received Pluvicto #3 this morning. No apparent side effects from #1 or #2. I was on Chemo (3 doses) and could feel the battle within; since changing to Pluvicto I have returned to myself, in most respects. We each react differently, but this has given me back an active life. Bloodwork after #2 showed lower PSA; 2.3 from 10.6. Bloodwork between #1 and #2 had PSA nearly unchanged. Original diagnoses Jan 2016, removal May 2016, 35 days of radiation July/Aug 2016.

Missed Lu trials Getting second injection Radium 223 on 28th Xofigo

Pretty much the same thing is happening to me....after the second Pluvicto injection, I was having a much harder time recovering from fatigue, malaise, loss of appetite and difficulties evacuating . My PSA had risen from 17 to 24, that's the highest jump I have had so far in my four years battle.My oncologist immediately schedule for a bone and upper body scan to see if more metastatis has occured. I am doing the scans tomorrow ( 2-26 ) . Depending on the results, he will evaluate weather to continue on with Pluvicto or not. I am glad i found your post and others. It is possible that the PSA my lower and rise indipendently from other factors I guess. The only sure way to determine progression lays in imaging.... a bit nervous about tomorrow, but I hoping the results will be ok. Thanks.

@tania27, I believe @dwpoole @vocalek @donalan were on a clinical trial for LU177 (Pluvicto). Glad to hear your husband is doing well. How are you doing?

I missed the trial as it was full They got me on Radium 223 as my mets is just in the bones Second injection 27th Feel great No hair loss or other affects like chemo
Had to go through a year of Xtandi first to qualify as its $9k and injection

If it fails then chemo PSA did go up to 14 in last 6 months after Xtandi stopped working

On Zolodex and Xgeva needles every 3 months

Is anyone in this group in the Novartis trial for LU177. This trial is 6 treatments of pluvicto prior to chemotherapy. My husband finished all 6 in early June of 2023. He is doing very well, although labs from his 9 month post treatment are not back yet.
We would like to know if there are others in the trial and how they are doing?

My husband had 4 treatments. It seemed to be working because lymph Mets were shrinking and PSA reduced. Suddenly his PSA jumped and a scan showed the bone Mets were growing. Treatment was halter. He is now waiting for word whether he qualifies for a clinical trial aimed at advanced prostate cancer. We had high hopes for Pluvicto, but we have heard it does work for many. I'd advise giving it a try.

I just got second round of Jevtana (carbazitaxel) and so far no significant side effect. I heard same thing as to it being better tolerated for most

Good for you! Every day is a blessing.

Get my third shot on January 11. I’m very happy to be in the program there’s always something new and exciting coming along. That gives us guys a little more hope and gives us a lot more time. Actually the side effects have been mostly good bad side effects or other issues that I’ve had with my health five and myalgia and arthritis. This isn’t as scary as it was 24 years ago. When I started had the operation came back over 100 chemo radiation on chest arm and back. Several times went through all the drugs. They all stopped working and here I am still alive leading a very nice quiet life with my family can’t golf but that’s not a big deal. Happy new year one and all.