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Anyone on Pluvicto (Lu 177), a new drug for prostate cancer?
My close friend has had Pluvecto treatment suggested to him by oncologists. It is relatively new, having been approved by the FDA in March 2022. Have any of you been given this drug? I have read it is radioactive material and patient needs to stay away 6 ft from others for at least 3 days so as not to contaminate them. He has not yet decided whether to take the treatment or not as he is feeling awful enough as is.
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I too am in recent recurrence (as previously outlined here in other threads), and I was truly pleased to see this thread on Pluvicto here today, because I'm kinda hoping that Pluvicto 'might' soon be recommended for me by my primary radiation oncologist, in addition to ADT.
However, I've been told that Pluvicto is typically reserved for recurrent patients whose cancer has spread outside of the pelvis, and unfortunately, I remain a bit confused as to the interpretation of the summary results of my own recent PSMA-PET scan. Specifically, the attending radiologist (who interpreted the scan results and wrote the summary report), and that subsequent radiation oncologist, both indicated that my cancer was "isolated to the gland itself" (i.e., "not having spread"), yet the highest detected SUV (standardized uptake value) of all tissues in the scan, was in the right seminal vesicle (a very high SUV of 21!), which is not "outside the pelvis", but which is clearly not "within the prostate gland" either! Hence, my confusion.
And I should probably add another source of personal confusion, in that Pluvicto is frequently cited as a "targeted medicine", yet I don't quite see how its a "medicine" at all? It appears to simply be a radiolabeled ligand, that specifically binds to the enzymatic surface glycoprotein PSMA (much like the PSMA-PET technique does), thereby delivering targeted radiation directly to the cancerous cells, but then, perhaps I'm wrong? Maybe my own definition of a "medicine" is inaccurate?
Anyway, I'm hoping my primary radiation oncologist, will clarify this discrepancy for me when I meet with him via tele-health this next week, but again, I'm sure hoping that Pluvicto just might be among his suggested list of available options for me.
@morlyn my dad is also having SEVERE dry mouth after first treatment of Pluvicto. Dropping weight too fast. Did yall ever find anything to help?
My PSA is undetectable just with Leuprolide however, I have a probable neural endocrine differentiation. Not all Prostate Cancer Emits PSA. The scans are definitive over the PSA. After my DociTaxel and carboplatin I still had some small Metastatic spots so we hammered it with the Pluvicto.
Did Doce not get PSA down With Carb how low is it now
Yes
Did you do 6 of doce and 6 of Carb
Very encouraging interpretation--good for you!
Dr.said this was a good scan. Hoping the areas still showing are dead cancer cells. Will continue on Leuprolide and Darolutamide and repeat scans in 3 months. When the before and after scans were pulled up side by side in the office today there was a very significant difference. Difficult to find the spots they charted but previous scan was easy to see.
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3 ReactionsStarting chemo Doc wont let me go on daralutimide as Xtandi failed after a year
what does Leuprolide do is it zolodex
Glad you can ask Dr. Kwon about the scan results from yesterday. Good luck and keep us posted.