Prostate cancer treatment: Any connection with rise in my ALT and AST?

I think it’s doubtful that the treatments affected your liver function enzymes.
Retesting is the best idea and perhaps looking for other explanations if the levels don’t come down. Serious problems usually result in much higher levels.

Well...yes, I did notice significant increases in my AST and ALT after completing my five SBRT radiation treatments.

I had been in the mid-20's to low 30's ranges for over a decade of consistent lab tests. But one month after completing radiation tests revealed my AST at 66 and ALT at 98 -- huge departures from my usual results.

When I asked my radiation oncologist, she stated it could not be from the radiation since the liver was not near the radiation being applied to the prostate.

Fortunately, my next AST and ALT tests three months later had returned to normal.

@kenk1962 I finished my radiation in April , will get another blood test in a few weeks hope it drops, don’t want to give up a nightly drink

@graybeard46 My best guess is that you will be okay.

I can't explain why, but I think our situations probably have something to do with the radiation treatments. I'm betting it's a temporary type of situation.

@kenk1962 hope you’re right no sex for16 months is killing me if I can’t drink heaven help us

@graybeard46 Amen.

Yes, my husband’s became elevated during radiation and Lupron. They have stayed elevated with continued Lupron treatment. Liver function is tested every three months on comp metabolic test along with his CBC. I have read that Lupron can cause a rise in liver enzymes and I also questioned my husband’s medical oncologist about them early on in his treatment.

Yes, ADT can significantly increase liver enzyme levels. I experienced this while on Orgovyx.

My husband has mildly elevated ALT and AST, he’s on Orgovyx and Nubequa. Because of this he has temporarily stopped the Nubequa and the liver enzymes are going down. When they return to normal he will start the Nubequa again, maybe at a lower dose.

@suzystation My wife and I have recently found no doctor wants to take credit for any conditions outside of the norm. It's getting ridiculous.