Do aromatase inhibitors (like anastrozole) cause weight gain?

Posted by riverwatcher @riverwatcher, Sep 8, 2020

Is there any connection between anastrazole and weight gain?

Interested in more discussions like this? Go to the Breast Cancer Support Group.

@crazydaisy

I am on Anastrozole and am gaining a lot of weight. Anyone else?

Jump to this post

Me too....gained alot of weight and my food and beverage selections are strict also.

REPLY
@riverwatcher

That's the one side effect that I seem to have. In spite of more exercise (stationary bike, because I need to use a walker) and strict attention to diet. But I feel the same as you - if that's the worst side effect, I can live with it.

Jump to this post

Agreed SISTER.... that is 1 side effect I can deal with.

REPLY
@auntieoakley

I can tell you this is not uncommon for a lot of drugs. The way it was explained to me was keeping everything regular prevents the see-saw effect of constipation and then diarrhea, for me it is Mira lax, every night. For my husband it is dulcolax every afternoon. Please talk to your doctor, no one should have to live this way. I went through what I refer to as death cramps. Have you talked to your doctor about this?

Jump to this post

I have not. I was not suspecting the Letrozole as the culprit when I saw him in August and I was not cramping. That started just days after the visit and just as I was leaving to go on a work trip to Omaha. I was so constipated that I vomited after that nights dinner and did not eat for the remainder of the conference I was attending. I was fearful of becoming ill again, so stuck mostly to liquids. I have an appointment at the end of the month to see him again and have lab work. In the interim, I will try the Miralax to see if it improves. Thank you for the advice.

REPLY
@pammyt

I have been taking Letrozole for 9 months now. I have chosen it as my only treatment for stage 4 bc in my bones. It shrunk the tumors and now I am in remission without new growth or mets, but I have noticed in the past month a change in bowel habits. I am constipated and bloated followed by diarrhea. I was camping and riding in the side by side this past weekend with my husband when I started having stomach cramps and had to find a bathroom quick! I have been home the past couple of days and today is the same. The only constant is the Letrozole.

Jump to this post

I can tell you this is not uncommon for a lot of drugs. The way it was explained to me was keeping everything regular prevents the see-saw effect of constipation and then diarrhea, for me it is Mira lax, every night. For my husband it is dulcolax every afternoon. Please talk to your doctor, no one should have to live this way. I went through what I refer to as death cramps. Have you talked to your doctor about this?

REPLY
@mugs24cancer

Has anyone experienced a change in bowel habits from taking letrozole?

Jump to this post

I have been taking Letrozole for 9 months now. I have chosen it as my only treatment for stage 4 bc in my bones. It shrunk the tumors and now I am in remission without new growth or mets, but I have noticed in the past month a change in bowel habits. I am constipated and bloated followed by diarrhea. I was camping and riding in the side by side this past weekend with my husband when I started having stomach cramps and had to find a bathroom quick! I have been home the past couple of days and today is the same. The only constant is the Letrozole.

REPLY
@mugs24cancer

Thank you so much for your reply! I seem to be regularly irregular but more diarrhea recently...almost wonder if it is IBS. I do Good Belly probiotics daily, also some Celestial Seasoning ginger mint wellness tea with probiotics, and Benefiber which I think is like Miralax. I follow a GERD diet and walk almost 2 miles everyday. Walking seems to be my “way out” to try to keep stress and anxiety at bay. I just need to get off the worry wheel. Take care!

Jump to this post

@mugs24cancer : I have been on Letrozole for 10 weeks now. First 2 weeks some mild hot flashes, then the bone and joint pain set in. Varies, but 2 days/week pretty intense, 1 day/week almost non-existent, the other days variable. Has not stopped me from most activities, but I’m walking slower because I’m taking shorter strides with the hip/butt pain. No weight gain yet, no digestive issues, no brain fog, occasional slight fatigue. Still, I am not happy about facing almost 5 years of this. Will discuss Zometa infusions with oncologist in a few weeks.

REPLY
@blue850

I'm on anastrozole, but yes, used to be very regular. Also had a few days of diarrhea. This seems to be one of the side effects that comes and goes, swinging between constipation and loose stool. I take a probiotic daily and if needed ginger tea with probiotic in it already. Bigalow makes a good one, just before bed. MiraLax is an effective and benign choice too.

Jump to this post

Thank you so much for your reply! I seem to be regularly irregular but more diarrhea recently...almost wonder if it is IBS. I do Good Belly probiotics daily, also some Celestial Seasoning ginger mint wellness tea with probiotics, and Benefiber which I think is like Miralax. I follow a GERD diet and walk almost 2 miles everyday. Walking seems to be my “way out” to try to keep stress and anxiety at bay. I just need to get off the worry wheel. Take care!

REPLY
@mugs24cancer

Has anyone experienced a change in bowel habits from taking letrozole?

Jump to this post

I'm on anastrozole, but yes, used to be very regular. Also had a few days of diarrhea. This seems to be one of the side effects that comes and goes, swinging between constipation and loose stool. I take a probiotic daily and if needed ginger tea with probiotic in it already. Bigalow makes a good one, just before bed. MiraLax is an effective and benign choice too.

REPLY

Thanks. I am glad I found this forum. It is very helpful to communicate with others going or haven gone through same thing.

REPLY

@mugs24cancer , I am hoping someone who takes or took letrozole will chime in, but I definitely had big changes after starting AI.
@blue850 , I am crossing my fingers that your body adjusts to the new drug but please bring it up to your doctor if it doesn’t get better. Although naps aren’t ALWAYS bad. Lol

REPLY
Please sign in or register to post a reply.