Do aromatase inhibitors (like anastrozole) cause weight gain?

Posted by riverwatcher @riverwatcher, Sep 8, 2020

Is there any connection between anastrazole and weight gain?

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@3dogngt

has anyone experienced weight loss after they have finished the meds? I just wonder if I will ever return to "normal".

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Slowly, it’s getting better. I was experiencing, as most have, swollen joints and limbs, and around the stomach area. The swelling is gone, and the weight is going. It’s slow, but it’s going. Good luck.

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@mistymar

I was on Anastrazole and maintained weight but other side effects, primarily constant muscle and joint pain, caused him to change me to exemestane. It’s better but as soon as I started the 3rd month, I started to gain weight with no other changes to eating or exercise. They just said same as above, doesn’t make you gain weight, just makes it harder to loose and causes redistribution of fat. Yet I gained 10# in 1 week after being the same average weight for over 2 years through all this. So I don’t know if I’ve just done enough to damage my metabolism or what. Can’t stop ai because I’m 100% ER with positive oncotype. So I guess just stick with it and do my best to try to maintain but it is really depressing.

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I'm in the same boat. I am ER+ and am taking Exemestane. I have gained 20 lbs. and eat next to nothing. So, I know it's not weight gain from over eating. I eat good things, just not alot of anything. It is VERY depressing. I've always been somewhat slender, but my stomach right now is ridiculous!!

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@auntiephil

I gained weight over the five years I was on anastrozole. I consumed less, because my appetite wasn’t very good, I practised yoga, and still gained. It’s coming off now that I’m finished my course of anastrozole.

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❤️❤️❤️❤️

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has anyone experienced weight loss after they have finished the meds? I just wonder if I will ever return to "normal".

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No major weight changes for me. I’ve been on Letrozole for 18 months and still struggle now and then with the same 5 lbs I’ve always battled, though it might take a bit longer to get it off with diet & exercise. My major complaint is joint and back pain!

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I gained weight over the five years I was on anastrozole. I consumed less, because my appetite wasn’t very good, I practised yoga, and still gained. It’s coming off now that I’m finished my course of anastrozole.

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I was on Anastrazole and maintained weight but other side effects, primarily constant muscle and joint pain, caused him to change me to exemestane. It’s better but as soon as I started the 3rd month, I started to gain weight with no other changes to eating or exercise. They just said same as above, doesn’t make you gain weight, just makes it harder to loose and causes redistribution of fat. Yet I gained 10# in 1 week after being the same average weight for over 2 years through all this. So I don’t know if I’ve just done enough to damage my metabolism or what. Can’t stop ai because I’m 100% ER with positive oncotype. So I guess just stick with it and do my best to try to maintain but it is really depressing.

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Here is what my pcp and new oncologist told me …they don’t necessarily make you gain weight but they DO make it VERY difficult to lose weight. I dad ER/PR Positive breast cancer so the new wonder drugs. Wegovy, etc, are HORMONE based and a big NO for me. There were two older weight loss meds that were not hormone based, Phentermine was the one my PCP prescribed. For the first time ever I was able to love about 20 pounds. I did not have any bad side effects (nervousness, etc) and plan to start another course this year as well. HTH!

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@oilermama

I believe there is. As others have said, it is a side effect that I have experienced up close and personal. And it seems to be belly fat,predominantly. My activity levels are higher than a year ago but no weight loss is happening. Of course, I look at it as,”if weight gain is the most serious side effect I am experiencing,I can live with it (unhappily).

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I have gained 20 pounds in less than a year. Trying to exercise through the neuropathy and pain in back and knees.

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@crazydaisy

I am on Anastrozole and am gaining a lot of weight. Anyone else?

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Me too....gained alot of weight and my food and beverage selections are strict also.

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