6 years now my left foot is worse does Cymbalta work

Welcome @tsk387, While you wait for members to respond, you might find it helpful to scan through the list of discussions and comments by members who have used Cymbalta to treat their neuropathy pain. Here's a link of search results that shows the discussions and comments - https://connect.mayoclinic.org/search/discussions/?search=cymbalta%20for%20neuropathy.

How long have you had neuropathy? Can you share a little more about your diagnosis and symptoms?

Cymbalta has worked well for me, 60mg once a day. It gave me my life back.

@tsk387
I had taken Cymbalta and it helped for a couple years then stopped working for me. Have you had EMG/nerve conduction studies of your lower limbs and small fiber neural skin punch biopsy done by a neurologist? Have you had Xrays and mri of your cervical and lumbar spine to see if your spinal cord or nerve roots are compressed? Have you been to a vascular specialist to see if you have any peripheral artery disease contributing to nerve damage due to poor blood flow in your leg? Have you tried taking alpha Lipoic acid or acetyl l carnitine supplements?

I have been taking Duloxetine for about 5 years for neuropathy in my toes (60 mg once a day). It did take away the electric shocks I was feeling and definitely helped my fibromyalgia, too. Side effects are dizziness. I also take 50 mg of pregablin twice a day to help the neuropathy pain. They work together well with dizziness being the worse side effect (the higher the doses, the worse the dizziness). Also weight gain is common. I still have bad pain spikes, particularly at night, but my sharp pain is not constant and really hasn't progressed beyond my toes. I used to live with ice packs before I got on these 2 meds. So they definitely help. However, there is no cure for neuropathy once it starts. You need to control what caused it (e.g. diabetes) so it doesn't spread to other peripheral nerves (like your hands), but it doesn't go away. Finding a way to control the burning, stinging, and cramping pain is essential to cope with it. Though I feel my PN is progressing slowly, particularly in reaching the end stage of total numbness, it has totally changed my life in terms of what I can do. I cannot sleep at night because the pain is greatest at that time, so I sleep during the day when it subsides. I cannot walk much even with a cane and I find I need to elevate my feet a lot throughout the day to make them feel better. But you need to keep moving as much as you can and control the pain as much as you can with meds or distractions (i. e., brain meds or distractions like loud music) and, of course, pray.