Newly diagnosed with gastro esophageal junction (GEJ) cancer

Posted by mike786 @mike786, Jul 26, 2023

42m, married 3 kids, esophageal junction cardia cancer
Hi all. I am diagnosed last week. My ct scan also show some lymph nodes swollen. Max 15cm. I had been two months ill with helicobacter as well. Could it be that these lymphs are swollen due to my infection and not cancer?

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Only at surgery they will be able to tell you - if you can get the surgery asap

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Sorry made a mistake. It was 1.5cm max i.e 15mm. Not 15cm.

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Ct scan report:
Abdomen:
Wall thickening esophagus gastric passage continuing to the cardia of the
stomach with extensive locoregional lymphadenopathy at the curvature
minor to 14mm. This lymphadenopathy extends caudally as well
para-aortic and paracaval. The largest gland is located between the vena
cava and infrarenal aorta and has a short axis diameter of 15 mm (image
116). Also retroperitoneal glands just caudal to the pancreas to 12
mm (image 110)
homogeneous liver without focal abnormalities. Spleen is not enlarged, spleen. Slim adrenal glands. Normal kidneys. Slim
intestinal package. No ascites. Skeleton:
No suspicious skeletal lesions. Conclusion:
Wall thickening esophagus gastric junction/cardia of the stomach with extensive
locoregional lymphadenopathy but also extensive lymphadenopathy both
para-aortic and paracaval to just proximal to the iliac bifurcation. No metastases elsewhere. Yours sincerely

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Biopsy report;
Based on guideline gastric carcinoma version 2.1 (2016) and oesophageal carcinoma 3.0 (2010)

Clinical Data and Macroscopy
Histological biopsy(s): esophagus
Type of acquisition mode: targeted from visible lesion
Number of esophageal biopsies: 5

Microscopy
Tumor type (WHO): adenocarcinoma nos
Degree of differentiation: grade 3
Mucous membrane esophagus: columnar
Intestinal metaplasia: not present
Active inflammation: severe

Additional research MMR/MSI
MLH1 loss: no
PMS2 loss: no
MSH2 loss: no
MSH6 loss: no

(Immuno)histochemistry
Other immunos / stains
PAS-D: positive
CDX2: focal positive
HER2 Immunohistochemistry: negative (score 0)
Status HER2: negative
PD-L1 test: 22C3
Number of tumor cells: = > 100 cells
Shape: Dx kit manufacturer
Tumor cells (TC): negative (< 1%)

Supplement microscopy
All tumor cells are strongly positive for PanCK, EBER is negative.

Some mucus vacuoles in the PasD.

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@mike786

Biopsy report;
Based on guideline gastric carcinoma version 2.1 (2016) and oesophageal carcinoma 3.0 (2010)

Clinical Data and Macroscopy
Histological biopsy(s): esophagus
Type of acquisition mode: targeted from visible lesion
Number of esophageal biopsies: 5

Microscopy
Tumor type (WHO): adenocarcinoma nos
Degree of differentiation: grade 3
Mucous membrane esophagus: columnar
Intestinal metaplasia: not present
Active inflammation: severe

Additional research MMR/MSI
MLH1 loss: no
PMS2 loss: no
MSH2 loss: no
MSH6 loss: no

(Immuno)histochemistry
Other immunos / stains
PAS-D: positive
CDX2: focal positive
HER2 Immunohistochemistry: negative (score 0)
Status HER2: negative
PD-L1 test: 22C3
Number of tumor cells: = > 100 cells
Shape: Dx kit manufacturer
Tumor cells (TC): negative (< 1%)

Supplement microscopy
All tumor cells are strongly positive for PanCK, EBER is negative.

Some mucus vacuoles in the PasD.

Jump to this post

PDL1 seems to be +
Did you discuss immunotherapy? Opdivo ?
It looks like my mom before surgery.

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Can you get the surgery asap ?

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I have called hospital even now for a quick appointment
They said next week. Does any one know how the results look like. Bad or worse

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Thanks for the tip. Opdivo seems like something i can use after treatment

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They tend to know with the barium that it's esophagus cancer, they check, recheck, consult.. they don't want mistakes, lawsuits and such. Your oncologist team will be thorough

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Hi @mike786, how are you doing?

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