Hi @spittendrigh. I'm a long-time longhauler like you. In March, I will hit 4 years.

Also like you, I have had the merry-go-round of symptoms over this time, including losing my autonomic functions (eating, sleeping, breathing). It took me until the 3 year mark to be able to begin taking even the mildest of medications again. (One dr. said, "this is a medication we give to ICU neonates it's so mild, and we'll start you on the lowest of doses". Nope. Had to stop after 2 days.) This change seemed to correlate with inflammatory blood markers returning to normal range (several of mine were really high). So I think it may be a systemic inflammation thing. I can take just about anything again now.

One thing about me I want you to know... I have improved over time, excruciatingly slowly it seemed, with even the worst of symptoms eventually relenting. It was very recently, at the 3 3/4 yr mark, that I seemed to almost miraculously return to quasi normalcy wrt most symptoms, except for my GI symptoms which are still out of control. I'm hoping this is a sign that Long Covid will improve with time. Whether that's time alone, or in combination with the myriad of things I have done/tried, we may never know. Just beyond happy to be here now!! I wish the same for you and everyone on this site.