Hi @handyman69 and welcome. Stage 4 tonsil cancer? Fine one day and the next not so much or were the symptoms being ignored until they could no longer be ignored? I don't mean to sound harsh but there has to be more to this story. Do you have a question or something to share about this clinical trial? I would imagine it is going to be strong Chemo for quite some time as by stage four, it has metastasized to the point where surgery and radiation would be everywhere and not feasible. Hopefully there has been an analysis of the type such as HPV16+ which can significantly change the type of Chemo required. Good luck and good healing.