So far, so good with my experiment eliminating both NAC and mucinex from twice/day regime. Will see how it goes. All I know is that I have slept much better since eliminating mucolytics. Important to note that I continue to neb levalbuterol and 7% saline twice daily.

Mucus is complicated, it seems. Answers are likely in this article, which I have yet to read but be my guest!
https://pubs.acs.org/doi/pdf/10.1021/acs.langmuir.0c02410

I would be VERY interested in hearing how your experiment with the no mucinex and no NAC for bronchiectasis. I tried NAC 600 twice daily for 1 1/2- 2 weeks and it seemed to make my mucus worse. I also currently take mucinex 600 ER daily and supplement that with liquid Guaifenison (Mucinex) when mucus seems to be more than usual. All that to go along with my daily airway clearance with albuterol, Pulmozyme, and 7% saline twice daily. Whew!!! I do think it is possible to over medicate certain conditions. Could someone please tell me more about the NJH Dr. who stated, No mucinex or NAC for Bronchiectasis. After all NJH is known as the leading respiratory medical facility in the U.S. thank-you.