Early treatment for my PsA was with Prednisone, Methotrexate injections, and progressed to biologics due to a severe & reoccurring case of Uveitis (sometimes associated with PsA). I started with Remicade (had a reaction, so I could not take it); and then Humira which I took very successfully for 5 years, until it caused too many infections. I then tried Cosentyx (too many side effects) and started Otezla for a couple years. Otezla only worked about 50% for me, so started Orencia infusions for 2 years. I had my last infusion in late August and have stopped to take a break due to upcoming surgery needed. (My Rheumatologist and I have discussed SimponiAria infusions as my next choice after surgery…if needed.) I may try to stay off any medication to see if my immune system has calmed down as I’ve aged (I am 68) which sometimes will happen. Sometimes older patients may be able to stop biologic treatment and use Medrol Dosepacks, and other more simple treatments if a flare occurs. I hope this has been helpful.