@sueinmn Last night I decided to do my own experiment. No mucinex nor NAC. For the first time in many weeks I slept through the night without waking from rumbles/noises in my chest. I nebbed levalbuterol & saline before dinner. I repeated the experiment this morning. Clearance seemed easier and faster. My breathing is better. I'll see how things go from here to rule out the placebo effect or fluke!

Also, as you suggested, it would be good to know why this is the case. Perhaps I was overmedicating? Also my sinuses seem to like mucinex. I plan to show my doctor the slide about mucolytic agents being a no-no for bronchiectasis; maybe she can explain the mechanics behind "disulfide bonds, mucin polymers, mucus viscosity".

From what I've gleaned in my reading, NJH along with Dr. Swensen encourage albuterol or levalbuterol and 7% saline only in bronchiectasis. What do the bronchiectasis experts at Mayo say?