Getting PMR into remission is the goal. Just about everybody starts with the prednisone because, as dadcue points out, it puts out the flame. Pain, stiffness often debilitating. Then the goal is to taper down the pred. But that’s where things get dicey. Some people are able to taper better than others. My PMR was managed but just barely for the last year. Even on 30mg of pred there was pain and stiffness and some really bad “ack I can’t walk” flares. My inflammation markers remained high. Doc added methotrexate to the pred and I was able to taper down to 10 but again it was just barely keeping things under control. Then at thanksgiving all hell broke loose and I couldn’t walk for three days. I started over. Long answer to your question but I added Kevzara just a month ago. I still take the methotrexate as well as prednisone but now I feel good. Inflammation markers are normal for the first time in a year. Stiffness and pain pretty much gone. It’s the Kevzara making the difference. The pathway forward is to get pred down below 10 and then off, then start decreasing methotrexate ultimately getting rid of that and down to only the Kevzara.