I very reluctantly started on prednisone and then found myself on it for longer than I wanted because another doctor had to run some tests to determine if I needed to triple my dose for some nerve pain. That was a two-month extension. I was at 10mg. I am now down to 3 mg and have never had break thru pain at night. I do take my prednisone after breakfast and before lunch. I have always taken it all at the same time. I wonder if my dosage timing has anything to do with not having break thru pain.

The half-life of prednisone is 3-4 hours. Meaning that half of it is out of your system in that time, then half of what remains is out of your system in another 3-4 hours. At the end of 8 hours you have approximately 25% of the dosage remaining. I use drugs.com as my subject matter expert resource.

I am experiencing fatigue daily but I discovered that prednisone can mess with your body's ability to convert T4 to T3 - these are the thyroid factors. Low T3, which is what I currently have, is hypothyroidism and one symptom is fatigue. My Endocrinologist is not treating it due the timeline to treat it is months and by then I will be off the prednisone. We will see it my body can recover on it's own. If not she will address it.

I am getting a bone scan this year to see how the prednisone robbed my bones. I am going to PT now to help rebuild some muscle strength I lost due to atrophy from my greatly reduced activity level due to PMR systemic pain.

Prednisone is not always your friend. It can be very naughty.

Just thought I would share in case it helps anyone.