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Can you take tymlos and prolia
Osteoporosis & Bone Health | Last Active: Aug 7 9:09am | Replies (39)Comment receiving replies
@burrell5 I may have read that Tymlos isn't effective after Prolia in the book "Great Bones." I tried to look it up and found this, pertaining to Forteo (similar) after Prolia, which is more hopeful:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620731/
" In the prospectively planned DATA-Switch study, we now test the hypothesis that the transition from teriparatide or combined teriparatide/denosumab to denosumab monotherapy and the transition from denosumab to teriparatide monotherapy will further increase BMD in postmenopausal osteoporotic women."
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Thank you @windyshores. It must have been in Great Bones where I read about Tymlos after Forteo. And thank you for sharing the study. I agree that it's very hopeful, though the combined treatment shown to be the most effective, would be incredibly expensive. Can you imagine what the side-effects could be when taking both at the same time?
In the Interpretation of that study it states, "In postmenopausal osteoporotic women switching from teriparatide to denosumab, BMD continued to increase whereas switching from denosumab to teriparatide results in progressive or transient bone loss."
For anyone who doesn't know about it, or is interested in learning more, this randomized control trial is cited and further explained in the recorded presentation that Dr. Benjamin Leder gave at the Cleveland Clinic about a year ago. The recording which is often referenced in this support group, is titled "Combined and Sequential Approaches to Osteoporosis Therapy". It can be viewed on YouTube.
Here's the link: https://youtu.be/WXoz1NeUgg8?si=Ka8vNnzsjDc9TZXA
It's a bit technical in parts, but well explained and very informative.