my personal experience is that I have been taking it for about 2 years, started on 50mg's. Not realizing over the first couple of months my skin would be itchy when I got out the shower. I hadn't changed anything that I use for shampoo or soap, nor did I change my laundry detergent. this went on for a few months but wasn't everyday. I thought and was scared I had shingles, so I went and got the shot just in case. a few more months go by and the itchiness (more like pins and needles on my arms and back), it was awful, it would stop after my body cooled down so still not thinking it was the medication. keep going forward, I was put on 100mg's because of some depression. About a month or so after that, I noticed my itchiness/pins and needles were happening most days. I started thinking I was allergic but still also thinking it could be dry and irritated skin because of the weather (I tend to have dry skin and have had eczema). Keep taking the 100mg's. A few more months go by, now I can't even take a shower and the pins and needles/itchiness start happening in the shower and I notice a red dry patch on my arm with white in the middle, oh boy, now I think I have ringworm. I couldn't go to the Dr., I was in between jobs with no insurance. So I try treating it myself with Lotrimin and cortisone, no avail, still getting worse. Now I know it is allergic reaction, so I go back down to the 50mgs for about a week, then every other day for a week, still not feeling better, even trying to put burn lotion on it. I have had enough so stop taking it (again I still have no insurance so no dr visit, just research on-line). This was 3 days ago. The first 2 days were fine, today not so much, I have become aggressive, weird dreams, bad dizziness and can't sleep. Well here I am trying to get thru work. Thank goodness my insurance kicks in in 8 days and I can go back to the doctor. Good luck and I will never use it again. PS, today was the first day with no itchiness so I KNOW it was the medication.