I was on .025 transdermal estrogen. That is the lowest dose and it has been shown to maintain density. After 5 years, I recently increased to .0375. I am currently seeing a menopause specialist and she wanted me to go to .05 but I was reluctant as I was concerned about the potential for breast tenderness and enlargement so I compromised with .0375. She felt that the slightly higher dose would provide a greater benefit. I've had no body changes or side effects on the new dose. It is still considered a very low dose. I have looked into testosterone and at this point, it seems that it is not recommended for women except in the case of low libido. There is little to no research on women taking it for osteoporosis. In addition, testosterone is processed and converted to estrogen so personally, I am not comfortable taking it and was recommended against it by my menopause specialist who has been prescribing HRT for decades.