I am 70 years old and I have been on hormone replacement therapy since 45 three times. I have tried to wean myself off and each time after 90 days, I beg my doctors to go back on. After my most recent withdrawal, My doctor did change me to an Estradiol patch and progesterone by mouth at night. She says the issue is taking the medicine orally they’re going through the liver creates issues, so I am thrilled to death to have found a Doctor who understands that quality of life is better than quantity.