It is so complicated, isn't it?! If Jim chooses radiation, he favors HDR brachy, either as mono-therapy or adding 4 months of ADT to the HDR brachy. His radiation oncologist prefers this dual therapy instead of EMRT + brachy, saying the addition of ADT is preferable because it covers the entire body. There are so many varying recommendations, it seems.
Jim would, of course, like to decrease post-treatment side effects (knowing the incontinence post-surgery and the many side effects of ADT). But most important is to choose a treatment that is most likely to eliminate a cancer recurrence and need for further therapy.
Bottom line, we think we're back to choosing prostatectomy, primarily because it will alert us to any recurrence as soon as possible. (Worrywart that I am, not knowing if recurrence might be happening since the PSA interpretation isn't as black and white regarding cancer status post-radiation will be stressful!) It seems that the sooner we know of recurrence, the sooner it can be addressed, with our health providers' guidance. We also like the fact that after surgery, the entire prostate will be biopsied, so we better understand the degree of seriousness of cancer at that time. And, as we understand it, after initial treatment with prostatectomy, more options remain for treating a possible recurrence than if radiation is done initially.
I wish we felt more confident in our understanding so as to feel confident we're makeing a best choice. It's just hard to know if our rationales for leaning toward RP are right-thinking. You seem to be very knowledgeable, russ777! IF you have any other points of further clarification or thoughts that may make things more clear to us, I would welcome hearing back from you. Thanks a lot for what you have shared! (I'm pretty sure I understand most of what you've said!) 😉 All the best to you!
Thanks. I assume with a 3+4 his risk group was favorable intermediate, assuming no concerning staging issues found on biopsy. That would prevent you from getting a PSMA PET scan in most cases. With the high risk evaluation in his Decipher test, that might motivate your RO or urologist, whichever is doing the overall management, to order a PSMA PET scan that your insurance might approve. That could potentially confirm that he actually needs ADT and radiotherapy instead of surgery.
Your thoughts on the post surgery pathology are good. Keep in mind that not only will the gland be removed, but also the seminal vesicles and some number of pelvic lymph nodes will be biopsied for pathology. You should inquire about what fraction of pelvic nodes will be removed/biopsied, which ones (some are more prone to spread cancer out of the pelvis than others) and discuss unilateral or bilateral nerve bundle sparing versus cure rates with the surgeon for those with high risk cancer.
As far as the systemic aspect of ADT goes, just keep in mind it is not curative. It can suppress the cancer, potentially for a very long time, but it is not cytotoxic like radiation or chemo.