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Concerned about the side effects of anastrozole
Breast Cancer | Last Active: Jul 28 9:25am | Replies (1934)Comment receiving replies
When I realized that my sudden major increase in side effects after one year on Anastrozole may have been related to a change in manufactured… I found a pharmacy where I could revert back to Anastrozole manufactured by Accord ( the original generic). My increased side effects faded back to the original manageable and mitigated ones… mostly joint stuff and interrupted sleep ( awake 2-3 hours in middle of night).
While figuring this out I found a route to try the BRAND ANASTROZOLE … ARIMIDIX !
Even less side effects and especially sleeping through the night!
Generics are not regulated by FDA… they have their own regulation body but the main ingredient ( Anastrozole in this case ) can vary up to 20% in either direction and fillers can be very different.
The BRAND is tightly regulated by FDA and cannot vary in ANY way from pill to pill.
The brand has worked for me.
Replies to "When I realized that my sudden major increase in side effects after one year on Anastrozole..."
Hmmm, the manufacturer on my bottle of Anastrozole says BRECKENRIDGE from my pharmacy.
I hope that that's o.k.
Generic drugs are regulated by the FDA. Supplements like vitamins are not.
I just posted a few days ago about how my issues started after my brand was switched. I had only minor issues my first 15 months with Anastrazole. Long story short, my digging showed that the first 15 months were Accord, and then I was switched to Breckenridge. Starting again on Accord after a month break. However my cancer provider tells me that my aggressive palpitations that went away after 9 days off of Anastrazole were NOT related to the meds. Hmmmm , we will see.
This is not true as to generics. (From the FDA website) FDA-approved generic medicines work in the same way and provide the same clinical benefit and risks as their brand-name counterparts. A generic medicine is required to be the same as a brand-name medicine in dosage, safety, effectiveness, strength, stability, and quality, as well as in the way it is taken. Generic medicines also have the same risks and benefits as their brand-name counterparts.
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I did brand name letrozole (Femara) despite the added cost 🙂