After I was taking Wellbutrin for a number of years, I felt like I was going down again, and my psychiatric NP added Mirtazapine. That helped me level out. Later I started taking Duloxetine - Cymbalta - for peripheral neuropathy, and though it didn't do much for neuropathy pain, I was motivated to do things that had been on my list for years. As you know, combining medications often has a good effect.

My wife does have trouble understanding why I continue therapy after 16 years. She has said in the past that I should be over it (whatever "it" is) by now and would like it if I would try going off some meds. But she hasn't said anything like that for awhile. I've told her when things she's said are unhelpful, and she's good about paying attention to that. I wonder what your son would suggest if you asked him how you can best support him, or what you might do or not do. You've probably had that conversation.

I have a psychiatric service dog who is also a member of my support team. She's very attentive to my mood and will nudge me to let her help me. My service dogs have been significant contributors to my mental well-being. Sadie is always with me, even right now as I lie in the ER, having a bunch of tests done. She's been beside me today for 9 hours, lying on her blanket next to my bed. She probably would stay here all night, but my wife and I are beyond ready to go home.

It sounds as though my depression is better controlled than your son's. Did Lithium help him? As I said, an add-on such as Abilify could be what he needs right now. Also, I've heard people say that an antidepressant has become ineffective after a while, and they have changed to a different medication.

I hope that his down times don't interfere with his getting a degree.

Jim