Tolerance is tolerance when it comes to opioids. They all work in the same receptors. The issue is Strength of effect and how much mme’s you are using in a day. The more you use up, the more pain receptors you are flooding.
Eventually they will be “numb” to the opioids and you will need what’s called a “vacation” to “reset” them.
This is done with NALOXONE. There are pain meds you can take during this period.
Methadone is one. It’s got a narrow dosage range. There’s also Talwin NX, and a combo Buprenorphine with NX. This is how you clean the receptors and can still get the relief you need.
It’s not easy, they aren’t as efficient as opioids but they do help.
Whoever said it was easy being a chronic pain patient has never been one.

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