I have stage 4 CKD and have also experienced episodes of severe itching from time to time. First off I try to stay well hydrated from the inside out as recommended and approved by my nephrologist. Also I tried to link the itching to anything else that might explain why it was and what to do about it. I mostly came up with external causes related to seasons, weather and temperature plus the associated clothing. For instance hot, humid, sweaty in the summer. Cold and dry during the winter heating season. I live in Minnesota. My husband has very sensitive skin and allergies so we use hypoallergenic hygiene products and household cleaners; so I felt comfortable ruling out products as the source of my itching. In addition to this I found that natural textiles rather than synthetics for clothing was helpful. For skin cleansers consider Basis, Eucerin, Cetaphil, Neutragena, Almay. For moisturizers try plain baby oil. I also like baby powder or plain talcum powder to help wick away sweat and too much moisture (in creases and crevices). Avoid fragrances and additives. Simple is better.