When I was at the 4 mg level I was taking it once a day before bedtime. The same applies now that I have been solidly at 1 mg and am very slowly moving towards a 1/2 mg dose. Actually, ever since I got below the 10 mg level I have taken my dose in the evening around 11:00 when I'm heading to bed. I do that because I learned years ago that inflammation peaks in the middle of the night around 3-4:00. Taking it before bed for me is most effective. although at times it really messed me up for sleeping. Now that I'm at such a low dose it isn't an issue any longer. When I was at higher doses I had to split my dose, 1/2 in the morning and 1/2 at night, because it seemed like my metabolism was burning up the dose too fast for it to last 24 hours.