Yes, I have Stage IV COPD , tried Daliresp (Brand Name) and had horrible side of effects, mostly mood and depression. Did not stay on it long and during the time that I was on it did not feel the benefits of decreasing secretions. With that said, I believe that one should give their system every opportunity to improve symptoms of this horrible disease and its worth a try. Just stop it if you develop symptoms that are not bearable, and then again you may not have any and it will work great. Good Luck