I have HR+ HER2- mbc and had been on Verzenio for 6 months then Abraxane chemo for 6 months before each began losing effectiveness. My oncologist is prescribing a newly approved immunotherapy pill called Truqap produced by AstraZenica. I have not started this treatment yet but reading indicates side effects similar to Verzenio et al. My oncologist said Truqap is not in the same family as Verzenio et al though. As a side note, I was also in a Kisqali trial during 2019-2020 before losing my eyesight to corneal damage caused by bacterial infections in each eye 6 months apart (I add this to warn users to be aware of any eye sensitivity and see your optometrist immediately). Here is a link to more information on Truqap https://www.astrazeneca.com/media-centre/press-releases/2023/truqap-approved-in-us-for-hr-plus-breast-cancer.html