Hello @balajik , I know this can be very scary and stressful especially going thru chemo a second time for your wife. I was 3c1 and have been NED for 2 1/2 years. I did 6 round of carbo/taxol, 25 rad and 3 brachy. I have to say for me the chemo was not as bad as I expected. I had a dear friend have chemo for ovarian and later breast, (she is doing fine) and it was much worse. I say that, hoping this maybe is a bit easier for her than the breast chemo. I am on the facebook group and maybe you are too? I would surely get another opinion if you are concerned even if it is online and even if she has started treatment. I was diagnosed during covid and had a second opinion at Duke and then a 3rd at UNC that was online. They are used to doing this. I wonder about the chemo when I hear about others but I am grateful to be NED and hopeful to stay well. I am also grateful to hear of all the others doing well on Keytruda and other drugs. I wish you both the best.