My pulmonologist told me take rifampin and ethambutol together with empty stomach once a day, take clarithromycin 500mg every 12 hours.So ,I take rif and ethambutol at morning when I get up,after an hour I take clarithromycin with food and other medications. I had the big3 already 1 year. I tolerate well, I eat some fermented food every day to avoid my digestive tract bacteria imbalance.I have being taken Arikayce inhaler 6 months,at first 2 months side effects was tough,but after that the side effects gradually disappeared I regained my appetite,energy,and crazy cough topped..I guess big portions of side effects were caused by allergies,after while boby will get use of it.