Unfortunately a great deal of the 3 yr. period I was in the hospital following my Stage 4 esophageal cancer surgery + a 2 mo. long coma post surgery where I was near death. From there moved to 4 different rehabs none of which seemed the least bit interested in helping me with the diarrhea problem. No doctors ever visited & no tests ordered either. When I finally got back home I began the search for ways to fix the problem. Was always told to just try pro-biotics but none of them ever helped at all. The most success I had was with trail mix. It really helped. I now have occasional episodes and my recent colonoscopy & stool sample tests came back 100% OK. Still no diagnosis. Thanks for the info. on Perdizone 5mg. Will discuss with my gastro doctor who just prescribed Visbiome for 60 day trial.